LI Hong-yue, WANG Qing, LIU Hong-mei, et al. Proventive Effects of Theaflavins on Ischemic Brain Injuries in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 172-174.
DOI:
LI Hong-yue, WANG Qing, LIU Hong-mei, et al. Proventive Effects of Theaflavins on Ischemic Brain Injuries in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(5): 172-174. DOI: 10.13422/j.cnki.syfjx.2015050172.
Proventive Effects of Theaflavins on Ischemic Brain Injuries in Rats
Objective: To investigate the effects of theaflavin aganist ischemic brain injuries in rats. Method: Sixty-four SD rats were randomly divided into 4 groups as following:sham operation group (Sham)
model group (Model)
theaflavin low and high dose group
which was administrated with theaflavin 20
40 mg·kg-1 respectively. Rats of Sham and Model group were administrated with equal-volume normal saline. Rats were treated with continued 7 days
and then ischemic brain injuries in rats were reproduced by middle cerebral artery occlusion(MCAO). After operation 24 h
rats were observed behavior and neurological behavior score by Longa method. Then
water content of brain tissue in rats was calculated in 6 rats selected from each group. Finally
another 10 rats in each group were determined superoxide dismutase(SOD)
malondialdehyde(MDA) and nitric oxide(NO) level in ischemic brain tissue by colorimetric methods. Result: Compared with Sham group
there were obvious behavioral disorders displayed in Model group
simultaneously water content of brain tissue
MDA and NO content were elevated
however
SOD activity was reduced. Compared with Model group
behavioral score and SOD activity in theaflavins groups were significantly ameliorated
yet water contents of brain tissue and MDA content were attenuated significantly. Besides
NO content was elevated significantly in theaflavins high dose group. Conclusion: Theaflavins can provent against ischemic brain injuries in rats.