Objective: To discuss the clinical effects of Gushen Shengfa pills combined Wuling capsules in treating alopecia areata disease with deficiency of liver and kidney symptoms and to investigate its regulatory effect on Th1/Th2 cell factor. Method: One hundred and twenty patients were randomly divided into the control group (60 cases) and the observation group (60 cases) by digital method. Patients in the two groups received minoxidil tincture for external use. Patients in the control group added 3 pieces of compound glycyrrhizin tablets and 2 pieces of compound cystine tablets thrice daily. Patients in the observation group added 2.5 g Gushen Shengfa pills and 3 pieces of Wuling capsules thrice daily. All patients received 3 months of treatment. Another 15 healthy subjects were assigned to the healthy group. Scores of hair loss area and position

light pull hair test and hair growth were conducted before and after therapy. Besides

Pittsburgh sleep quality index (PSQI) scores were conducted. Levels of serum interferon-γ (IFN-γ)

interleukin-12 (IL-12)

IL-4 and IL-10 were tested. Result: The curative effect in the observation group was superior to that in the control group (P<0.05). The main symptoms scores including hair loss area and position

light pull hair test and hair growth

and the signs and PSQI scores in the observation group were lower than those in the control group after treatment (P<0.01). Compared with the healthy group

levels of IFN-γ and IL-12 were higher

the IL-4 and IL-10 levels were lower in both the two groups before treatment (P<0.01). After therapy

IFN-γ and IL-12 levels decreased

IL-4 and IL-10 levels increased in the observation group

the results were better than those in the control group (P<0.01). Conclusion: Gushen Shengfa pills combined Wuling capsules could improve the quality of sleep

control the Th1/Th2 balance

promote the growth of hair. Its clinical effect is superior to the treatment of compound glycyrrhizin tablets combined with compound cystine tablets.