Objective: To discuss the curative effects of Shenqi Jiangtang granules

Ginkgo leaf capsules jointed with mecobalamine and α-lipoic acid in treating diabetes peripheral neuropathy (DPN) and to investigate its influence on levels of oxidative stress indicators and serum cystatin C (Cys-C). Method: One hundred and four DPN patients were randomly divided into the Western medicine group (52 cases) and the combination group (52 cases)

Patients in the Western medicine group took 0.5 mg mecobalamine tablets thrice daily and 0.6 g thioctic acid capsules once daily. On the basis of therapy in the Western medicine group

patients in the combination group added 2 g Shenqi Jiangtang granules and 2 pieces of Ginkgo leaf capsules thrice daily. All patients in the two groups received 3 months of treatment. Integral scores of symptoms and Toronto (Toronto clinical scoring system

TCSS) clinical grading were conducted before and after therapy. Motor conduction velocity (MNCV) and sensory conduction velocity (SNCV) of median nerve

ulnar nerve

the common peroneal nerve

anterior tibial nerve were detected. Levels of serum total antioxidant capacity (TAOC)

superoxide dismutase (SOD)

malondialdehyde (MDA) and Cys-C were tested before and after treatment. Result: The curative effects in the combination group were superior to those in the western medicine group (P<0.05). After therapy

clinical symptom integral and Toronto clinical scores in the combination group were lower than those in the western medicine group (P<0.01). MNCV and SNCV of median nerve

ulnar nerve

common peroneal nerve

anterior tibial nerve in the combination group had higher improvement as compared with those in the Western medicine group (P<0.01). Levels of SOD

MDA and Cys-C in the combination group were inferior to those in the western medicine group (P<0.01)

while the TAOC level was higher than that in the Western medicine group (P<0.01). Conclusion: The curative effects of Shenqi Jiangtang granules

Ginkgo leaf capsules jointed with mecobalamine and α-lipoic acid therapy is superior to using Western medicine alone in treating DPN disease. Its mechanism may be related to relieving oxidative stress injury and reducing serum Cys-C level.