Objective: To evaluate the effectiveness and safety of salvianolate injection (SI) on acute cerebral infarction (ACI) versus conventional treatment (CT). Method: Systematic literature searches were performed in PubMed

Cochrane Library

CBM

CNKI and WanFang datbase from Jan 1994 to Apr 2014.Randomized controlled trials (RCTs) on SI treating ACI were enrolled. Two reviewers screened articles according to the inclusion and exclusion criteria

extracted data and assessed the quality of the included studies independently. The Meta-analysis was performed using RevMan 5.2. Result: A total of 12 RCTs involving 1 574 patients were included. The results of Meta-analysis demonstrated that SI had higher curative rate [OR=2.78

95%CI(1.87

4.12)

P<0.000 01] on 6 RCTs

improvement evaluation of NIHSS [OR=-2.05

95%CI (-2.51

-1.59)

P<0.000 01] on 5 RCTs

and amendment many endothelia parameters as compared with the CT group. No severe adverse reactions after SI treatment were reported. Conclusion: Current evidence shows SI may be superior to CT in treating ACI patients in recovery rate

vascular endothelial cell protection and improvement hemorheology index. However

due to lack of enough high-quality studies

SI has to be further studied by conducting more strictly-designed

multicenter

large-scale and double-blind RCTs.