ZENG Jin-di, XIONG Lei, XIE Yin, et al. Determination Analysis of Glass Transition Temperature of Traditional Chinese Medicine Extract Powder[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(6): 1-5.
DOI:
ZENG Jin-di, XIONG Lei, XIE Yin, et al. Determination Analysis of Glass Transition Temperature of Traditional Chinese Medicine Extract Powder[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(6): 1-5. DOI: 10.13422/j.cnki.syfjx.2015060001.
Determination Analysis of Glass Transition Temperature of Traditional Chinese Medicine Extract Powder
Objective: To establish a measuring method for glass transition temperature of traditional Chinese medicine(TCM) extract powder by differential scanning calorimetry(DSC) and provide a reference for application of glass transition theory in solid preparation process of TCM. Method: DSC was developed to determine glass transition temperature of TCM extract powder in order to confirm existence of glass transition phenomenon in TCM extract powder.Single factor tests were adopted to investigate effects of thermal history
flow rate of carrier gas
heating rate
sample volume and other parameters on glass transition temperature
precision of this determination was investigated by Dixion. Result: Nitrogen as a carrier gas
flow rate of carrier gas was 40 mL · min-1
sample amount was 6 mg
heating rate was 10 mg · min-1.Outlier analysis showed under 95% confidence level
determination of glass transition temperature met requirements of test method.Glass transition temperature of Angelicae Sinensis Radix
Astragali Radix
Isatidis Radix
Crataegi Fructus
Lycii Fructus
Chrysanthemi Flos
Rhei Radix et Rhizoma
Shenlingcao were 68.9
77.0
75.8
35.8
3.4
56.0
56.3
80.0 ℃
respectively. Conclusion: This method is simple with good precision
which can be used to determine glass transition temperature of TCM extract powder.
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