Influence of Permeation Enhancers on  Transdermal Permeation of Glabridin

WANG Yan; WANG Li-feng; XI Ya-bin; ZHANG Pei-wen; HE Hao-ke; LI Qing; ZHANG Si-pei; LU Jie; ZHANG Yan-jun

doi:10.13422/j.cnki.syfjx.2015060014

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Influence of Permeation Enhancers on Transdermal Permeation of Glabridin

更新时间：2024-01-04

- Influence of Permeation Enhancers on Transdermal Permeation of Glabridin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 6, Pages: 14-16(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015060014
  CLC： R284;R285
- Published：2015
- 稿件说明：
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WANG Yan, WANG Li-feng, XI Ya-bin, et al. Influence of Permeation Enhancers on Transdermal Permeation of Glabridin[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(6): 14-16.
DOI：

WANG Yan, WANG Li-feng, XI Ya-bin, et al. Influence of Permeation Enhancers on Transdermal Permeation of Glabridin[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(6): 14-16. DOI： 10.13422/j.cnki.syfjx.2015060014.

摘要

目的: 考察促渗剂对光甘草定体外经皮渗透性能的影响

为该化合物经皮给药系统的开发提供参考。方法: 采用HPLC测定光甘草定含量

流动相乙腈-水-冰乙酸(55:44:1)

检测波长282 nm。选取小鼠背部皮肤

通过Franz垂直扩散池考察光甘草定的透皮性能

考察氮酮、冰片、丙二醇对光甘草定乳剂透皮吸收的影响。结果: 光甘草定的透皮吸收率较低

促渗剂能有效使其透过皮肤。不同促渗剂对光甘草定促透作用顺序为5%氮酮组>5%丙二醇组>5%冰片组>单体组

稳态渗透速率分别为4.938

3.041

2.950

2.583 μg ·cm-2 ·h-1

滞后时间依次为0.056

0.180

0.059

0.167 h。结论: 不同促渗剂均能促进光甘草定的经皮渗透效果

以氮酮为最佳。

Abstract

Objective: To investigate effects of different permeation enhancer on in vitro transdermal permeation of glabridin through rat's skin and provide a reference for development of transdermal drug delivery system of this compound. Method: HPLC was adopted to determine the content of glabridin with mobile phase of acetonitrile-water-glacial acetic acid(55:44:1) and wavelength at 282 nm.The back skin of rats was used

Franz vertical diffusion cell was adopted to investigate transdermal performance of glabridin

effects of azone

borneol and propylene glycol on transdermal permeation of glabridin were observed. Result: Glabridin was difficult to penetrate the skin by itself

but it could penetrate the skin effectively by adding permeation enhancer.Effect of enhancers on glabridin was ranked as follows:5% azone > 5% propylene glycol > 5% borneol > monomer

permeation rates of steady state were 4.938

3.041

2.950 and 2.583 μg · cm-2 · h-1

the lag time were 0.056

0.180

0.059 and 0.167 h

respectively. Conclusion: Each penetration enhancers can promote transdermal effect of glabridin

and azone is the best one.

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