XIAO Zheng-guo, LIU Xiao-shuan, LI Xi-xiang, et al. Optimization of Formula of Yuhong Nanoemusion by Conductivity-pseudo-ternary Phase Diagram[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(6): 17-19.
DOI:
XIAO Zheng-guo, LIU Xiao-shuan, LI Xi-xiang, et al. Optimization of Formula of Yuhong Nanoemusion by Conductivity-pseudo-ternary Phase Diagram[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(6): 17-19. DOI: 10.13422/j.cnki.syfjx.2015060017.
Optimization of Formula of Yuhong Nanoemusion by Conductivity-pseudo-ternary Phase Diagram
Objective: To optimize formula of Yuhong nanoemulsion and provide a reference for improving of quality stability of this preparation. Method: When composition of nanoemulsion changed
conductivity change was observed on the basis of magnetic stirring at a constant temperature
quadratic regression model was adopted to determine critical points of phase transition
then formula of Yuhong nanoemulsion was optimized by making classic ternary phase diagram. Result: Optimum formula was as following:mixed emulsifier with hydrophilic-lipophilic balance value of 11.26
ratio of emulsifier and co-emulsifier 2.603:1
with mixture of glycerol-ethanol(3:1) as a co-emulsifier
refined sesame oil as oil phase
Wahaha purified water as water phase
oil phase-water phase-mixed emulsifier(28.99:63.74:7.27). Conclusion: This optimized formula is stable and feasible with higher drug-loading
it is suitable for improving stability of Yuhong ointments.
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Related Institution
Guizhou Provincial Engineering Center for Efficient Utilization of Natural Pharmaceutical Resources, Featured Key Laboratory of Pharmacology and Pharmacological Evaluation of Natural Medicine in Guizhou Colleges and Universities,Guizhou Medical University-Guiyang Municipal Joint Key Laboratory,Key Laboratory of Optimal Utilization of Natural Medicinal Resources,School of Pharmaceutical Sciences,Guizhou Medical University
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School of Pharmacy,Guangxi University of Chinese Medicine, South China Branch of National Engineering Research Center for Manufacturing Technology of Traditional Chinese Medicine Solid Preparation