Antithrombotic Effect and Thrombolysis Mechanism of Zhachong Shisan Wei Pill

LIU Yue-ying; Baoluer; SONG Bao-hua; ZHANG Dong-li; ZHAO Zhong-xiao; DONG Li-gang; XUAN Li-ying; WANG Chun-gui; KANG Wei-dong; LIN Lin; HUO Wan-xue; ZHANG Li-wei; LIU Lan-ying; BAO Hong

doi:10.13422/j.cnki.syfjx.2015060127

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Antithrombotic Effect and Thrombolysis Mechanism of Zhachong Shisan Wei Pill

更新时间：2024-01-04

- Antithrombotic Effect and Thrombolysis Mechanism of Zhachong Shisan Wei Pill
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 6, Pages: 127-130(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015060127
  CLC： R285.5
- Published：2015
- 稿件说明：
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LIU Yue-ying, Baoluer, SONG Bao-hua, et al. Antithrombotic Effect and Thrombolysis Mechanism of Zhachong Shisan Wei Pill[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(6): 127-130.
DOI：

LIU Yue-ying, Baoluer, SONG Bao-hua, et al. Antithrombotic Effect and Thrombolysis Mechanism of Zhachong Shisan Wei Pill[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(6): 127-130. DOI： 10.13422/j.cnki.syfjx.2015060127.

摘要

目的: 研究扎冲十三味丸溶栓作用及机制。方法: 大鼠随机分为5组:模型组、扎冲十三味丸高、中、低3个剂量(1.728

0.864

0.432 g ·kg-1)组、复方丹参滴丸0.12 g ·kg-1组。运用动静脉环路法测定扎冲十三味丸对大鼠旁路血栓形成的影响;通过在体外血栓的溶解百分率

研究该药体外血栓溶解作用;通过给药后不同时间大鼠纤维蛋白原降解产物(fibrindeg-radationproducts

FDP)

研究该药的体内溶栓作用。结果: 与模型组比较

扎冲十三味丸各剂量组

可使血栓质量明显降低(P<0.001)

血栓长度明显降低(P<0.05

P<0.001)。模型组与正常对照组比较

血液中的FDP含量有所增加

与模型组比较

扎冲十三味丸中、高剂量组血栓降解产物FDP含量显著升高(P < 0.05)。结论: 扎冲十三味丸在体内、外有显著的抗栓和溶栓作用

降解纤维蛋白是抗血栓与溶栓的作用机制之一。

Abstract

Objective: To investigate the antithrombotic effect and the mechanism of the thrombolysis effect of mongolian medicine Zhachong Shisan Wei pill. Method: The rats were randomly divided into 5 groups:control group

Zhachong Shisan Wei pill in high

middle and low dose (1.728

0.864

0.432 g · kg-1)groups

and compound Danshen dripping pills treatment group with 0.12 g · kg-1.The effects of Zhachong Shisan Wei pill on the formation of thrombus in rats were observed through the way of arteriovenous loop. The dissolution percentage of thrombus in vitro was measured. The fibrinogen degradation product (FDP) of rat at different time after administration was studied in vivo. Result: Compared with the model group

Zhachong Shisan Wei pill with different dose could significantly decrease the weight of thrombus (P<0.001)

the length of thrombus (P<0.05

P<0.001).Model group increased the content of FDP compared with the control group. Compared with model group

effect of Zhachong Shisan Wei pill on the FDP content of the thrombus degradation products was decreased(P < 0.05). Conclusion: Zhachong Shisan Wei pill have significant antithrombotic and thrombolysis effects in vivo and in vitro. Degradation of fibrin is one of the mechanisms of antithrombotic and thrombolysis.

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