Objective: This research was aimed to study effects of tomato leaf aqueous extract (TLAE) against oxidative stress induced by acute inflammatory. Method: Fifty SD rats were randomly divided into control group

model group and three TLAE treated groups of different dose (3.19

1.59

0.80 g · kg-1 · d-1). The TLAE was orally given once a day within 10 days. Acute inflammation was induced by intraperitoneal injection of lipopolysaccharide (4 mg · kg-1) after the end of gavage administration. The levels of CuZn-superoxide dismutase(CuZn-SOD)

glutathione peroxidase 1(GSH-Px-1)

interleukin-6(IL-6) and tumor necrosis factor α(TNF-α) in serum were measured by enzyme-linked immunosorbent assay (ELISA).Gene expressions of CuZn-SOD and GSH-Px-1 in peripheral blood leucocyte were detected by reverse transcription-polymerase chain reaction (RT-PCR). Result: TLAE at 3.19

1.59 g · kg-1 · d-1 enhanced either the gene expressions of CuZn-SOD

GSH-Px-1 or the levels of them in serum. Furthermore

the decreased levels of TNF-α and IL-6 in serum were detected. Conclusion: The orally given TLAE can markedly restrain the oxidative stress companied with the LPS-induced acute inflammatory.