Objective: The aim of this article was to observe the acute

genetic and long-term toxicity of the Korean Red Ginseng to evaluate its safety. Method: Test of the maximum tolerance dose(MTD) was used to detect the acute toxicity

and the genetic toxicity test was evaluated by Ames test

micronucleus test of born marrow in mice and sperm shape abnormality test in mice). The rats were given Korean Red Ginseng in high

medium and low(6.0

3.0

1.5 g · kg-1) dose continuously for 30 days

to detect the long-term toxicity. Then we conducted the effects on blood cytology indexes

blood biochemical indexes

weight coefficient of organs

and the histopathology examination

routine examinations and reversibility study. Result: There was no obvious toxic symptom in the acute toxicity trial (in the rats in different sexual

the MTD were both higher than 12.0 g · kg-1 treated with Korean Red Ginseng). The results of genetic toxicity test were all negative. The results of long-term toxicity trial indicated that there were no significant differences in appearance

behavior

body weight

blood cytology indexes

blood biochemical indexes

organ/body ratio

and pathematology examination in the rats in all the three dosage groups (6.0

3.0

1.5 g · kg-1) as compared to the control group. The reversibility study demonstrated that there was no delayed toxicity in the rats in all the three dosage groups as compared to the control group. Conclusion: Korean Red Ginseng is highly safe with neither acute toxicity nor genetic toxicity.