Objective: To discuss the revival effect and the mechanism of Angong Niuhuang pills in treating coma caused by acute cerebral infarction. Method: Eighty patients with coma caused by acute cerebral infarction were randomly divided into the Western medicine group (40 cases) and the experimental group (40 cases) by a random number table. Patients in the Western medicine group received routine Western medical therapy. Based on the treatment of Western medicine group

patients in the experimental group added 3 g Angong Niuhuang pills once daily. All patients in both two groups received 7 days of treatment. Before and 3

7 days after treatment

scores of Glasgow coma scale (GCS) and the national institutes of health stroke scale (NIHSS) were graded. Brain oedema was evaluated. Levels of high sensitivity C-reactive protein (hs-CRP)

interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) were detected. Result: The curative efficacy of NIHSS in the experimental group was superior to that in the Western medicine group (P<0.05). At the third and seventh day after treatment

the total scores of eye opening response

verbal response

movement of limbs and GCS in the experimental group were lower (P<0.05)

score of NIHSS was lower than those in the Western medicine group (P<0.01). After treatment

levels of hs-CRP and TNF-α were lower (P<0.01)

and the level of IL-10 was higher than those in the Western medicine group (P<0.01). Volume of edema decreased more obviously and the amelioration of midline shift was better in the experimental group than that in the Western medicine group (P<0.01). Conclusion: Based on the treatment of routine Western medical therapy

Angong Niuhuang pills could make altered consciousness and ameliorate neurological function of patients. The effect may be related to relieving inflammatory response and edema

and promoting the recovery of neurological function.