Objective: To optimize preparation process of Penyankang suppositories and provide a reference for its clinical application. Method: With extracting amounts of chlorogenic acid and salvianolic acid B

dry extract rate as comprehensive evaluation index

orthogonal test was adopted to optimize water extraction technology of Penyankang suppositories by taking extraction times

the amount of water and extraction time as factors;with comprehensive score of the content of tetrahydropalmatine and dry extract rate as index

effects of the amount of ethanol

extraction time and ethanol concentration on ethanol extraction technology were investigated by orthogonal test.Taking appearance

hardness

melting point and dissolution as indexes

forming process of Penyankang suppositories was optimized by single factor tests. Result: Optimum water extraction technology was as follows:extracted two times with eight times the amount of water for one hour each time;extracting amounts of chlorogenic acid and salvianolic acid B were 2.778

30.314 mg·g-1.Optimum ethanol extraction technology was as follows:extracted two times with four times the amount of 60% ethanol for one hour and a half each time;extracting amount of tetrahydropalmatine was 0.758 mg·g-1.Optimized forming process was 36 type of adeps solidus as matrix

the content of polysorbate-80 1.5%

bath temperature at 50 ℃. Conclusion: These optimized processes are suitable

feasible and suitable for industrial production of Penyankang suppositories.