Determination of AsSand AsO in Huafeng Dan

CAO Guo-qiong; ZHANG Yong-ping; XU Jian; GAO Li; LIAO Xiao-gang

doi:10.13422/j.cnki.syfjx.2015070054

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Determination of AsSand AsO in Huafeng Dan

更新时间：2024-09-23

- Determination of AsSand AsO in Huafeng Dan
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 7, Pages: 54-56(2015)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2015070054
  CLC： R286.0
- Published：2015
- 稿件说明：
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CAO Guo-qiong, ZHANG Yong-ping, XU Jian, et al. Determination of AsSand AsO in Huafeng Dan[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 54-56.
DOI：

CAO Guo-qiong, ZHANG Yong-ping, XU Jian, et al. Determination of AsSand AsO in Huafeng Dan[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 54-56. DOI： 10.13422/j.cnki.syfjx.2015070054.

摘要

目的: 建立化风丹中不溶性砷盐和可溶性砷盐的含量测定方法

为该制剂的质量控制提供参考。方法: 采用滴定法和紫外分光光度法分别测定18批化风丹中二硫化二砷和三氧化二砷的含量。结果: 建立的二硫化二砷含量测定方法重复性好

平均加样回收率97.61%

RSD 2.0%。三氧化二砷在4~16 μg与吸光度线性关系良好

平均回收率97.77%

RSD 2.1%。18批化风丹中二硫化二砷质量分数0.012~0.021 3 g·g-1

平均质量分数0.018 4 g·g-1

差异系数13.3%;三氧化二砷质量分数75.24~124.55 μg·g-1

平均质量分数92.99 μg·g-1

差异系数15.3%。结论: 建立的含量测定方法简单、准确

为化风丹质量标准提升提供实验依据。不同批次化风丹中二硫化二砷和三氧化二砷含量差异较大。

Abstract

Objective: To establish determinations of soluble arsenic salt and insoluble arsenic salt in Huafeng Dan in order to provide a reference for quality control of this preparation. Method: Contents of As2S2 and As2O3 in 18 batches of Huafeng Dan were determined by titration and UV spectrophotometry

respectively. Result: This established determination of As2S2 was reproducible with average recovery of 97.61%.Linear range of As2O3 was 4-16 μg with average recovery of 98.42 %.In 18 batches of samples

mass fraction of As2S2was 0.012-0.021 3 g·g-1 with average value of 0.018 4 g·g-1

difference coefficien was 13.3%;mass fraction of As2O3 was 75.24-124.55 μg·g-1 with average value of 92.99 μg·g-1

difference coefficien was 15.3%. Conclusion: These determinations are simple and accurate

they can provide experimental basis for improvement of quality standards of Huafeng Dan.Contents of As2S2and As2O3 in different batches of samples are quite different.

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Related Institution

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