Objective: To investigate the effect of Mori Cortex before and after honey processing on serum nitric oxide(NO)

lipid peroxidation (LPO)

interleukin-4(IL-4) and interferon(IFN-γ) of asthmatic rats

to study the anti-asthmatic mechanism of honeyed Mori Cortex. Method: Wistar rats were randomly divided into control group

model group

dexamethason 0.4 mg·kg-1group

the crude and honey processed Cortex Mori 1.08

3.24 g·kg-1 groups.Asthma rat model was established by sensitization and stimulation with ovalbumin(OVA) conjuncted with Al (OH)3.The latent period of class Ⅱasthma in 10 min

bronchial alveolar lavage fluid(BALF) eosinophil number

the levels of NO

LPO

IL-4 and IFN-γ in serum were determined. Result: Compared with the control group

the latent phase was significantly shorter

the BALF eosinophil number and the levels of NO

LPO

IL-4 in serum were significantly increased in the model group(P < 0.01). The group could also significantly decreased the levels of IFN-γ(P < 0.001).Compared with the model group

the latent phase was significantly longer

the BALF eosinophil number and the levels of NO

LPO

IL-4 in serum were significantly reduced in honey processed Mori Cortex and crude Mori Cortex 3.24 g·kg-1 groups(P < 0.05). The groups could also significantly increased the levels of IFN-γ(P < 0.01). Conclusion: The Mori Cortex before and after honey processing can significantly reduce the number of inflammatory cells in BALF of asthmatic rat and impact the levels of cytokines

thereby improving airway inflammation in asthma and symptoms of bronchial asthma.