MO Wei-bin, BU Kai, HUANG Li-li, et al. Effects of Mogroside on Expression of HSP mRNA and Protein in Gastric Tissue of Exhaustive Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 103-106.
DOI:
MO Wei-bin, BU Kai, HUANG Li-li, et al. Effects of Mogroside on Expression of HSP mRNA and Protein in Gastric Tissue of Exhaustive Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 103-106. DOI: 10.13422/j.cnki.syfjx.2015070103.
Effects of Mogroside on Expression of HSP mRNA and Protein in Gastric Tissue of Exhaustive Rats
Objective: Study on the expression of gastric tissue heat shock protein (HSP70) and HSP70 mRNA after exhaustive exercise in rats which pre-exercise supplement of mogroside(Mog)
to preliminary research the mechanism of mogroside. Method: Fifty healty male Sprague-Dawley rats were randomized into five groups
each consisting of 10 rats:the quiet group (NC)
the exercise group (ME)
the administration of Mog in low dose exercising group (MogL)
the administration of Mog in middle dose exercising group (MogM) and the administration of Mog in high dose exercising group (MogH). The rats were administrated by professional gavage once a day half an hour before exercising. This administration was continuously gaved six days in one week
and lasted for six weeks. The low
middle and high doses are respectively 100
200
400 mg·kg-1
while the rats in control group were administrated of pure physiological saline at the same dose. The rats were killed after 6-week training. The expression of gastric tissue protein HSP70 and HSP70 mRNA were measured according the corresponding kit method respectively. Result: The expression of gastric tissue protein HSP70 and HSP70mRNA were higher in exercise control group than these in NC group (P<0.05). The expression of gastric tissue protein HSP70 and HSP70 mRNA in MogL
MogM and MogH were higher than these in NC group and ME group (P<0.05
P<0.01). Conclusion: Supplement of Mog could improve the expression of gastric tissue protein HSP70 and HSP70 mRNA. This could play an important role to reduce gastric ulcer
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