BO Hai-mei, TIAN Chun-yu, BO Jian-zhu, et al. Effect of Zishen Qinggan Jiangtang Compound on PTP1B and Oxidative Stress in Type 2 Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 111-113.
DOI:
BO Hai-mei, TIAN Chun-yu, BO Jian-zhu, et al. Effect of Zishen Qinggan Jiangtang Compound on PTP1B and Oxidative Stress in Type 2 Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 111-113. DOI: 10.13422/j.cnki.syfjx.2015070111.
Effect of Zishen Qinggan Jiangtang Compound on PTP1B and Oxidative Stress in Type 2 Diabetic Rats
Objective: To study the effect of Zishen Qinggan Jiangtang compound(ZQJC) on glucose
protein tyrosine phosphatase 1B(PTP1B)expression
superexide dismutase(SOD)
malondialdehyde(MDA) and free fatty acide(FFA) in type 2 diabetic mellitus (T2DM) rats. Method: Ten rats were randomly selected as normal group
type 2 diabetes model was induced with high sucrose-fat diet and STZ ip for 30 mg·kg-1
rats were randomly divided into groups:model group
metformin(Met) group(0.14 g·kg-1·d-1
ig)
ZQJCL group(0.9 g·kg-1·d-1
ig)
ZQJCM group(1.8 g·kg-1·d-1
ig)and ZQJCH group(3.6 g·kg-1·d-1
ig)
10 rats in each group. fasting blood glucose(FBG) was detected at 2nd week and 4th week
and the level of SOD
MDA
FFA in the rats' serum and PTP1B expression in liver at 4th week were measured after the treatment. Result: Compared with the normal group
the blood glucose levels of model group were increased (P<0.01)
PTP1B expressions in liver of model group were increased (P<0.01).After treatment
compared with model group
ZQJC group could obviously decrease the levels of FBG
MDA and FFA (P<0.05
P<0.01)
improve SOD activity (P<0.05) and inhibit the PTP1B expression in liver. Conclusion: ZQJC has the effect of regulating glucose metabolism of the T2DM rats
inhibition of oxidative stress and PTP1B expression in liver could be one of the mechanisms.
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Jie-hua HUANG
Xiao-min DENG
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Geng-xu WU
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Biao LUO
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Related Institution
Guangxi University of Chinese Medicine
The First Affiliated Hospital of Guangxi University of Chinese Medicine
Key Laboratory of Traditional Chinese Medicine Health Care,Beijing University of Chinese Medicine
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