Effect of Xiaopi Hewei Decoction in Treating 45 Patients with Chronic Atrophic Gastritis

SHEN Li-juan; WEI Yu-na

doi:10.13422/j.cnki.syfjx.2015070191

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Effect of Xiaopi Hewei Decoction in Treating 45 Patients with Chronic Atrophic Gastritis

更新时间：2024-09-23

- Effect of Xiaopi Hewei Decoction in Treating 45 Patients with Chronic Atrophic Gastritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 7, Pages: 191-194(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015070191
  CLC： R259
- Published：2015
- 稿件说明：
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SHEN Li-juan, WEI Yu-na. Effect of Xiaopi Hewei Decoction in Treating 45 Patients with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 191-194.
DOI：

SHEN Li-juan, WEI Yu-na. Effect of Xiaopi Hewei Decoction in Treating 45 Patients with Chronic Atrophic Gastritis[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 191-194. DOI： 10.13422/j.cnki.syfjx.2015070191.

摘要

目的: 观察消痞和胃方治疗慢性萎缩性胃炎(CAG)的临床疗效及对血清白介素-8

11(IL-8

IL-11)和肿瘤坏死因子-α(TNF-α)的影响。方法: 将90例CAG患者随机按数字表法分为对照组和观察组各45例。两组均口服兰索拉唑片

30 mg

1次/d;和多潘立酮片

10 mg

3 次/d。连续使用6周。若幽门螺旋肝菌(Hp)阳性

再采用标准4联根除方案进行治疗。对照组口服香砂六君丸

9 g/次

2次/d。观察组采用消痞和胃方内服

每天1剂。两组疗程均为4个月。进行治疗前后中医证候、胃镜下征象及病理积分评价;检测治疗前后血清IL-8

IL-11和TNF-α水平。结果: 经Ridit分析

观察组疾病疗效优于对照组(P<0.05)

中医证候疗效优于对照组(P<0.05);治疗后观察组中医证候、胃镜下征象及病理积分均低于对照组(P<0.01);治疗后观察组IL-8

IL-11和TNF-α水平低于对照组(P<0.01)。结论: 在质子泵抑制剂和胃动药治疗的基础上

消痞和胃方能减轻CAG临床症状、改善胃黏膜病变

减轻炎症反应

这有利于阻止胃癌前病变发展。

Abstract

Objective: To observe the curative effects of Xiaopi Hewei decoction on chronic atrophic gastritis (CAG) disease

and to investigate its influence on serum interleukin-8 (IL-8)

IL-11 and tumor necrosis factor-α (TNF-α). Method: Ninety patients with CAG disease were randomly divided into the control group (45 cases) and the observation group (45 cases). Patients in both two groups took 30 mg lansoprazole tablets once daily and 10 mg domperidone tablets thrice daily for continuous 6 weeks. If Helicobacter pylori (Hp) is positive

standard quadruple eradication regimen was adopted. The patients in the control group added 9 g Xiangsha Liujun pills twice daily. Patients in the observation group added 1 dose Xiaopi Hewei decoction once daily. All patients in both two groups received 4 months of treatment. Traditional Chinese medicine syndromes

signs under gastroscope and pathological integral were evaluated. Levels of serum IL-8

IL-11 and TNF-α were detected before and after therapy. Result: The curative effects and the clinical effects of traditional Chinese medicine syndrome in the observation group were superior to those in the control group (P<0.05). Scores of traditional Chinese medicine syndromes

signs under gastroscope and pathological integral in the observation group were less than those in the control group (P<0.01). After treatment

standards of IL-8

IL-11 and TNF-α in the observation group were inferior to those in the control group (P<0.01). Conclusion: Based on proton pump inhibitors and stomach medicine treatment

adding Xiaopi Hewei decoction could reduce clinical syndrome

improve gastric mucosa lesions

relieve the inflammation of patients with CAG disease. It is helpful to prevent precancerous lesions of gastric cancer.

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Related Institution

Medical Department of Integrated Traditional Chinese and Western Medicine Hospital of Xinjiang Uygur Autonomous Region

College of Traditional Chinese Medicine， Xinjiang Medical University

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Hebei Key Laboratory of Turbidity Toxin Syndrome， Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research （Hebei）， Hebei Provincial Hospital of Traditional Chinese Medicine

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