Effect of Liuwei Dihuang Wan Combined Huangqi Sanqi Oral Liquids in Treating 48 Patients with Early-stage Kidney Damage Aroused by Hypertension

MA Mei; MEI Feng; BA Ying-gui; CHEN Bi-qin

doi:10.13422/j.cnki.syfjx.2015070199

您当前的位置：

首页 >

文章列表页 >

Effect of Liuwei Dihuang Wan Combined Huangqi Sanqi Oral Liquids in Treating 48 Patients with Early-stage Kidney Damage Aroused by Hypertension

更新时间：2024-09-23

- Effect of Liuwei Dihuang Wan Combined Huangqi Sanqi Oral Liquids in Treating 48 Patients with Early-stage Kidney Damage Aroused by Hypertension
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 7, Pages: 199-202(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015070199
  CLC： R259
- Published：2015
- 稿件说明：
移动端阅览
MA Mei, MEI Feng, BA Ying-gui, et al. Effect of Liuwei Dihuang Wan Combined Huangqi Sanqi Oral Liquids in Treating 48 Patients with Early-stage Kidney Damage Aroused by Hypertension[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 199-202.
DOI：

MA Mei, MEI Feng, BA Ying-gui, et al. Effect of Liuwei Dihuang Wan Combined Huangqi Sanqi Oral Liquids in Treating 48 Patients with Early-stage Kidney Damage Aroused by Hypertension[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(7): 199-202. DOI： 10.13422/j.cnki.syfjx.2015070199.

摘要

目的: 探讨六味地黄丸联合黄芪三七口服液对高血压早期肾损害的保护作用及对炎症因子和凝血纤溶系统的影响。方法: 95例患者采用随机按数字表法分为对照组47例和联合组48例。对照组口服马来酸依那普利片

10 mg/次

1次/d;氨氯地平阿托伐他汀钙片

10 mg/次

1次/d

口服。联合组在对照组治疗的基础上加用六味地黄丸

6 g/次

3次/d

和黄芪三七口服液

10 mL/次

2次/d

口服。两组疗程均为12周。检测治疗前后24 h尿微量白蛋白 (mAlb)

尿微量白蛋白与肌酐的比值(ACR)

胱抑素(CysC)

β2微球蛋白(β2-MG)

尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)

白细胞介素-6(IL-6)

肿瘤坏死因子-α(TNF-α)

血浆D-二聚体(D-D)和血浆纤维蛋白原检测(FIB)

尿素氮(BUN)和肌酐(Cr);进行治疗前后肝肾阴虚兼血瘀证评分。结果: 经Ridit分析

联合组血压控制情况及中医证候疗效均优于对照组(P<0.05);治疗后联合组mAlb和ACR水平低于对照组(P<0.01)

两组BUN和Cr治疗前后变化不明显

均在正常范围内;治疗后联合组CysC

β2-MG和NAG水平均低于对照组(P<0.01);治疗后联合组D-D

FIB

IL-6和TNF-α水平均低于对照组(P<0.01)。结论: 采用六味地黄丸和黄芪三七口服液与西药常规疗法的联合方案对高血压早期肾损害的保护优于单纯西药治疗

其作用机制可能与减轻炎症反应

调节凝血纤溶系统有关。

Abstract

Objective: To discuss the protective effect of the combination of traditional Chinese and Western medicine in treating early-stage kidney damage aroused by hypertension

and to investigate its influence on inflammation and coagulation-fibrinolysis system. Method: Ninety-five patients were randomly divided into the control group (47 cases) and the combination group with traditional Chinese and Western medicine treatment (48 cases) by a random number table. Patients in the control group received 10 mg enalapril tablets and 10 mg amlodipine once daily. Based on the treatment of the control group

patients in the combination group added 6 g Liuwei Dihuang Wan thrice daily and 10 mL Huangqi Sanqi oral liquids twice daily. All patients in two groups received 12 weeks of treatment. Before and after treatment

24-h microalbuminuria (mAlb)

ratio of microalbuminuria and creatinine (ACR)

cystatin C (CysC)

β2-microglobulin (β2-MG)

urinary N-acetyl-β-D-glucosaminidase (NAG)

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

plasmic D-dimer (D-D)

fibrinogen (FIB)

urea nitrogen (BUN) and creatinine (CR) were detected. Scores of liver-kidney yin deficiency combined with blood stasis were graded. Result: The blood-pressure control and the curative effect of Chinese medical symptom in the combination group were superior to those in the control group (P<0.05). After treatment

levels of mAlb and ACR in the combination group were lower than those in the control group (P<0.01). But the changes of levels of BUN and Cr were not obvious

and they were within normal limits. Levels of CysC

β2-MG

NAG

D-D

FIB

IL-6 and TNF-α were lower than those in the control group (P<0.01). Conclusion: The effect of Liuwei Dihuang wan and Huangqi Sanqi oral liquid combined routine Western medicine therapy is superior to using Western medicine treatment alone. Its mechanism of action may be related to reducing the inflammatory response and regulating coagulation-fibrinolysis system.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Efficacy of Modified Da Chengqitang by Enema on Treatment if Postoperative Inflammatory Intestinal Obstruction

Protective Effect of Liuwei Dihuang Wan and its Constituents Absorbed into Blood After Oral Administration on Hydrocortisone Inducing Renal Deficiency in Rat

Effect of Liuwei Dihuang Wan on Vascular Endothelial Grouth Factor Expression and Cyclin D3 Gene in Spontaneous Breast Carcinoma in Mice

Effects of Liuwei Dihuang Wan on Animal Senile Dementia Models with Deficiency of the Kidney

Effect of Different Traditional Chinese Medicine for Nourishing Yin on Lung Chemical Carcinogenesis and Antitumor Immune Function in Mice

Related Author

Gang LI

Wen-yun WANG

Zhong-fu MA

Feng-chang ZHENG

Jie-xiang TIAN

Cheng-ji ZHAO

WANG Xi-jun1

ZHANG Ning1

Related Institution

The Second Hospital of Lanzhou University

Gansu Cancer Hospital

The Affiliated Hospital of Gansu College of Traditional Chinese Medicine

Jiangxi University of Traditional Chinese Medicine

Jiangxi University of Traditional Chinese Medicin

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰