REN Ye, GE Zheng-yan, JIN Long, et al. Investigation of Molding Process of Jiangtang Xiaozhi Tablets and Determination of Ursolic Acid in This Tablets[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 13-16.
DOI:
REN Ye, GE Zheng-yan, JIN Long, et al. Investigation of Molding Process of Jiangtang Xiaozhi Tablets and Determination of Ursolic Acid in This Tablets[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 13-16. DOI: 10.13422/j.cnki.syfjx.2015080013.
Investigation of Molding Process of Jiangtang Xiaozhi Tablets and Determination of Ursolic Acid in This Tablets
Objective: To provide a reference for industrial production and quality control of Jiangtang Xiaozhi tablets by optimizing its molding process and establishing determination of ursolic acid in this preparation. Method: With appearance
friability
disintegration time and others as indexes
molding process of Jiangtang Xiaozhi tablets was optimized by single-factor tests.HPLC was employed to determine the content of ursolic acid in Jiangtang Xiaozhi tablets with mobile phase of methanol-0.05% phosphoric acid water (90:10)
column temperature of 2 ℃ and detection wavelength at 215 nm. Result: With 15% pregelatinized starch and 5% lactose as filling agent
92% ethanol as wetting agent
adding 3% crosslinking polyvinylpolypyrrolidone internally and externally as disintegrant
0.3% magnesium stearate as lubricant.A good linearity of ursolic acid was in the range of 0.398-3.980 μg
the average recovery was 96.96%
the mass fraction of ursolic acid in samples was 2.22 mg·g-1. Conclusion: This optimized molding process is stable and feasible.This determination is simple
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