Chemical Constituents from the Fruits of  and Their Neurotrophic Activity

LIU Yu-hong; ZHANG Wen-yu; JIANG Hai-qiang

doi:10.13422/j.cnki.syfjx.2015080067

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Chemical Constituents from the Fruits of and Their Neurotrophic Activity

更新时间：2024-01-04

- Chemical Constituents from the Fruits of and Their Neurotrophic Activity
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 8, Pages: 67-69(2015)
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2015080067
  CLC： R284.1
- Published：2015
- 稿件说明：
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LIU Yu-hong, ZHANG Wen-yu, JIANG Hai-qiang. Chemical Constituents from the Fruits of and Their Neurotrophic Activity[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 67-69.
DOI：

LIU Yu-hong, ZHANG Wen-yu, JIANG Hai-qiang. Chemical Constituents from the Fruits of and Their Neurotrophic Activity[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 67-69. DOI： 10.13422/j.cnki.syfjx.2015080067.

摘要

目的: 对茺蔚子中神经营养活性部位的化学成分进行分离

追踪活性成分。方法: 采用硅胶、Sephadex LH-20、高效制备液相等方法进行分离纯化

根据质谱、核磁共振技术鉴定化合物结构

通过PC12细胞神经轴突生长促进作用测定神经营养活性。结果: 分离得到5个化合物

分别鉴定为橙黄胡椒酰胺乙酸酯(1)

auraptenol(2)

1-亚油酸单甘油酯(3)

刺槐素(4)和β-谷甾醇葡萄糖苷(5)

其中化合物1可以明显促进PC12细胞神经轴突的生长。结论: 化合物1~5均为首次从该属植物中分离得到

化合物1显示良好的神经营养活性。

Abstract

Objective: To isolate neurotrophic activity compounds from the fruits of Leonurus japonicus. Method: Silica gel

Sephadex LH-20 and preparative HPLC were used for isolation and purification. The structures of compounds were elucidated by MS and NMR spectra. Neurotrophic activity was evaluated on the neurite outgrowth of PC12 cells. Result: Five compounds were obtained and identified as aurantiamide acetate (1)

auraptenol (2)

1-monolinolein (3)

acacetin (4)

and β-sitosterol glucopyranoside (5). Compound 1 could significantly enhance the neurite outgrowth of PC12 cells. Conclusion: Compounds 1-5 were isolated for the first time from the genus Leonurus

compound 1 exhibited neurotrophic activity.

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Related Institution

Key Laboratory for Standardization of Chinese Medicines，Ministry of Education， Shanghai Key Laboratory for Compound Chinese Medicines，Institute of Chinese Materia Medica， Shanghai University of Traditional Chinese Medicine

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Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

School of TCM,Guangdong Pharmaceutical University

Key Laboratory of Basic and Applied Research of Northern Medicine,Ministry of Education,Heilongjiang Key Laboratory of Pharmacodynamic Material Basis of Traditional Chinese Medicine (TCM) and Natural Medicine,Heilongjiang University of Chinese Medicine

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