Anti-gout Effect of Various Fractions from Plantaginis Semen

ZENG Jin-xiang; BI Ying; XU Bing-bing; WEI Juan; REN Gang; XIONG Hao-zhong; ZHU Ji-xiao; ZHU Yu-ye; LUO Guang-ming

doi:10.13422/j.cnki.syfjx.2015080132

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Anti-gout Effect of Various Fractions from Plantaginis Semen

更新时间：2024-01-04

- Anti-gout Effect of Various Fractions from Plantaginis Semen
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 8, Pages: 132-135(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015080132
  CLC： R285.5
- Published：2015
- 稿件说明：
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ZENG Jin-xiang, BI Ying, XU Bing-bing, et al. Anti-gout Effect of Various Fractions from Plantaginis Semen[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 132-135.
DOI：

ZENG Jin-xiang, BI Ying, XU Bing-bing, et al. Anti-gout Effect of Various Fractions from Plantaginis Semen[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 132-135. DOI： 10.13422/j.cnki.syfjx.2015080132.

摘要

目的: 探讨车前子部位群的抗痛风活性与机制

为后续研究提供参考依据。方法: 以系统溶剂法提取分离车前子。90只昆明种小鼠

随机分为9组

每组10只

分别为正常组

高尿酸血症组(模型组)

别嘌呤醇组(0.01 g·kg-1)

总提物组(25 g·kg-1)

石油醚组(25 g·kg-1)

二氯乙烷组(25 g·kg-1)

乙酸乙酯组(25 g·kg-1)

正丁醇组(25 g·kg-1)

水部位组(25 g·kg-1)。除正常组外

其余各组采用氧嗪酸钾盐诱导小鼠急性高尿酸血症模型

ig给予相应药物

正常组和模型组给予等体积生理盐水

连续给药7 d。观察车前子总提物及5个部位对小鼠血清尿酸水平及肝脏黄嘌呤氧化酶(XOD)活性的影响。结果: 系统溶剂法提取分离车前子得到5个部位

分别为石油醚、二氯甲烷、乙酸乙酯、正丁醇、水部位。与正常组比较

模型组小鼠血清尿酸的水平与XOD活性明显升高(P<0.01);与模型组比较

别嘌呤醇、车前子总提物及各不同部位均可降低小鼠血清尿酸的水平与XOD活性(P<0.05

P<0.01)。结论: 车前子及不同提取部位具有一定的抗痛风作用。

Abstract

Objective: To study the anti-gout effect and mechanism of Plantaginis Semen(PS) extract parts on the level of uric acid in hyperuricemia mice. Method: Five fractions including the petrol ether extract

the dichloromethane extract

the ethyl acetate extract

the butanol extract and the water-soluble extract were obtained by systematic solvent extraction. 90 Kunming mice were randomly divided into 9 groups:the normal group (normal saline)

the hyperuricemia group (normal saline)

the allopurinol group (0.01 g·kg-1)

the total extract of PS(TPS

25 g·kg-1) and the five fractions groups (25 g·kg-1).The hyperuricemia mice were induced by using oxygen oxazine acid potassium. The mice were administrated of the corresponding medicines for 7 days

and then the level of uric acid and the activity of xanthine oxidase were observed. Result: TPS and five fractions were obtained. Compared with the normal group

the level of uric acid and the activity of xanthine oxidase increased obviously in the hyperuricemia group (P<0.01). All treatment groups could reduce the level of serum uric acid obviously

and inhibit the activity of xanthine oxidase of hyperuricemia mice (P<0.05

P<0.01). Conclusion: The PS and its different extracts have good anti-gout effect in hyperuricemia mice.

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Related Author

WANG Xiao-yun

ZHOU Qiang

ZENG Jin-xiang

WEI Juan

BI Ying

WANG Xiao-yun

ZHU Ji-xiao

ZHU Yu-ye

Related Institution

Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province,Jiangxi University of Traditional Chinese Medicine

Jiangsu Kanion Pharmaceutical Co. Ltd.

Nanjing University of Chinese Medicine

School of Pharmaceutical Science and Technology， Tianjin University

School of Chinese Materia Medica，Tianjin University of Traditional Chinese Medicine

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