Effect of Gansui Banxia Tang on Functions and Morphology in Rat Heart and Kidney

WANG Fu; CHENG Xiu-juan; ZHANG Da-wei; ZHENG Pan; LIU Bin; LI An-xiang; LI Xiao-yan

doi:10.13422/j.cnki.syfjx.2015080155

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Effect of Gansui Banxia Tang on Functions and Morphology in Rat Heart and Kidney

更新时间：2024-01-04

- Effect of Gansui Banxia Tang on Functions and Morphology in Rat Heart and Kidney
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 8, Pages: 155-159(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015080155
  CLC： R285.5
- Published：2015
- 稿件说明：
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WANG Fu, CHENG Xiu-juan, ZHANG Da-wei, et al. Effect of Gansui Banxia Tang on Functions and Morphology in Rat Heart and Kidney[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 155-159.
DOI：

WANG Fu, CHENG Xiu-juan, ZHANG Da-wei, et al. Effect of Gansui Banxia Tang on Functions and Morphology in Rat Heart and Kidney[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 155-159. DOI： 10.13422/j.cnki.syfjx.2015080155.

摘要

目的: 探讨甘遂半夏汤水煎液对正常大鼠心脏、肾脏的慢性毒性作用。方法: 将80只SD大鼠随机分为甘遂半夏汤高、中、低剂量组(37

18.5

9.25 g·kg-1)及正常组

各组大鼠采用等体积ig

ig体积均为0.02 mL·g-1。给药组ig给药

正常组ig给蒸馏水。给药90 d。最后1次给药后禁食15 h

各组随机抽取一半大鼠

采用全自动生化分析仪检测心功能相关指标磷酸肌酸激酶(CK)

乳酸脱氢酶(LDH)和α-羟丁酸脱氢酶(α-HBDH)及肾功能相关指标血尿素(UREA)

血肌酐(CREA)和尿酸(UA)。取心、肾

HE染色观察大体形态和组织学形态。剩余动物停药后继续观察2周

重复上述检查指标。结果: 在给药期和恢复期

与正常组比较

各组心、肾功能指标均无显著差异

心脏、肾脏大体形态和组织学形态均未见显著性异常变化。结论: 长期服用甘遂半夏汤水煎液对大鼠心、肾功能及形态学无显著影响。

Abstract

Objective: To explore the chronic toxicity of Gansui Banxia Tang (GBT) on heart and kidney of rats. Method: Eighty healthy SD rats were randomly divided into four groups:the normal group

the high-

middle-

and low-dose GBT groups (37

18.5

9.25 g·kg-1). The corresponding medicines at 0.02 mL·g-1were intragastrically administrated to rats for 90 days. After the last dose

the blood samples of the half rats from each group were collected. The heart function indexes including creatine phosphate kinase (CK)

lactic dehydrogenase (LDH) and α-hydroxybutyric dehydrogenase (α-HBDH)

and the kidney function indexes including blood urea (UREA)

serum creatinine (CREA) and uric acid (UA) were detected. The morphology and histology of the heart and kidney were observed by HE staining. The remaining rats in each group were observed continuously for two weeks

and the above indexes were detected again. Result: In medicine taking and during following observation

there were no significant differences for the relative function indexes and the change of morphology in heart and renal between any two groups. Conclusion: GBT has no remarkable effects on heart and renal function

and morphology of rats by long-term medication.

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