WANG Fu, CHENG Xiu-juan, WANG Bang-min, et al. Effect of Gansui Banxia Tang on Blood Routine, Blood Glucose and Morphology in Rat Thyroid[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 165-168.
DOI:
WANG Fu, CHENG Xiu-juan, WANG Bang-min, et al. Effect of Gansui Banxia Tang on Blood Routine, Blood Glucose and Morphology in Rat Thyroid[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 165-168. DOI: 10.13422/j.cnki.syfjx.2015080165.
Effect of Gansui Banxia Tang on Blood Routine, Blood Glucose and Morphology in Rat Thyroid
Objective: To explore the chronic toxicity of Gansui Banxia Tang (GBT) on blood routine
blood glucose (GLU) and thyroid morphology of rats. Method: Eighty healthy SD rats were randomly divided into four groups:the normal group
the high-
middle-
and low-dose GBT groups (37
18.5
9.25 g·kg-1). The corresponding medicines at 0.02 mL·g-1were intragastrically administrated to rats for 90 days. After the last dose
the blood samples of the half rats from each group were collected. The blood routine indexes including red blood cell (RBC)
white blood cell (WBC)
hemoglobin (HGB)
platelet (PLT) and GLU were detected. The morphology and histology of the thyroid were observed by HE staining. The remaining rats in each group were observed continuously for two weeks
and the above indexes were detected again. Result: In medicine taking
compared with the control group
the number of WBC significantly increased in high-dose GBT group (P<0.05)
the number of WBC had no significant changes in the middle-and low-dose GBT groups
the number of RBC
HGB and PLT had no significant changes in all dose GBT groups. While in medicine taking and during the following observation
GLU showed no significant changes in all dose GBT groups. No obvious change for morphology of the thyroid was observed. Conclusion: GBT could increase the number of white blood cell reversibility by long-term
medication. But there were no effects on the number of RBC
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