NIE Jun, SONG Bin. Zhizhu Kuanzhong Capsules Combined Rabeprazole Sodium Enteric-coated Tablets in Treating 50 Patients with Gastroesophageal Reflux Disease[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 194-197.
DOI:
NIE Jun, SONG Bin. Zhizhu Kuanzhong Capsules Combined Rabeprazole Sodium Enteric-coated Tablets in Treating 50 Patients with Gastroesophageal Reflux Disease[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 194-197. DOI: 10.13422/j.cnki.syfjx.2015080194.
Zhizhu Kuanzhong Capsules Combined Rabeprazole Sodium Enteric-coated Tablets in Treating 50 Patients with Gastroesophageal Reflux Disease
Objective: To observe the curative efficacy of Zhizhu Kuanzhong capsules combined rabeprazole sodium enteric-coated tablets in treating gastroesophageal reflux disease (GERD)
and to investigate its influence on patients' quality of life. Method: One hundred patients with GERD were randomly divided into the control group (50 cases) and the observation group (50 cases) by a random number table. Patients in both two groups received 20 mg rabeprazole sodium enteric-coated tablets in the morning and evening. Patients in the control group added 5 mg mosapride citrate tablets thrice daily. Patients in the observation group added 3 Zhizhu Kuanzhong capsules thrice daily. All patients in two groups received 8 weeks of treatment. Before and after treatment
scores of GERD questionnaire (GERDQ)
health inventory of SF-36 and deficiency of spleen and stagnation of Qi were graded. Result: After therapy
the curative effect of inflammation and Chinese medical syndrome in the observation group were superior to those in the control group (P<0.05). Eight dimensions scores including SF-36 scale physiological function
physiological function
body pain
general health
life energy
mental health
social function and emotional function in the observation group were better than those in the control group (P<0.05). Besides
scores of GERDQ and spleen deficiency and Qi stagnation syndrome in the observation group were inferior to those in the control group (P<0.05). Conclusion: Zhizhu Kuanzhong capsules jointed rabeprazole could reduce the clinical symptoms and signs
enhance the life quality of GERD patients. Its clinical curative effect is superior to using Western medicine treatment alone.
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