LI Huan, ZHOU Xue-ping, LU Yan. Discussions on Research Strategies of Compatibility for Attenuating Toxicity of Herbs Based on Metabonomics[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 226-229.
DOI:
LI Huan, ZHOU Xue-ping, LU Yan. Discussions on Research Strategies of Compatibility for Attenuating Toxicity of Herbs Based on Metabonomics[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(8): 226-229. DOI: 10.13422/j.cnki.syfjx.2015080226.
Discussions on Research Strategies of Compatibility for Attenuating Toxicity of Herbs Based on Metabonomics
The aim of this study was to explore the application of metabonomics technology in the research on the attenuation strategy by compatibility of traditional Chinese medicine (TCM). By analyzing the advantages of metabonomics used in the research on compatibility for attenuating toxicity of TCM
methods and content of compatibility for attenuating toxicity of TCM based on metabonomics was put forword. Metabolomics was a rapidly developed new technology after genomics
transcriptomics and proteomics
which is characterized by global
dynamic
comprehensive. Metabonomics studies display great potential in compatibility for attenuating toxicity of herbs as significant component of system biology. The application of metabonomics technology in the research on the attenuation strategy by compatibility of TCM should focus on four aspects
including identification of toxic components of drug metabolite group and effective ingredient
ascertainment of toxicity target organ of TCM and toxicity biomarkers
mechanism of toxicity control
and the analysis of correlation between toxic components of system modeling and attenuated activity of compatibility for attenuation synergia. Metabonomics has a vast potential in the research of attenuation strategy by TCM.