ZHOU Xue, HE Zhi-yong, XUE Yu-chen, et al. Investigation of Polymer Materials and Optimization of Preparation Process of Puerarin Sustained-release Microspheres[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(9): 14-18.
DOI:
ZHOU Xue, HE Zhi-yong, XUE Yu-chen, et al. Investigation of Polymer Materials and Optimization of Preparation Process of Puerarin Sustained-release Microspheres[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(9): 14-18. DOI: 10.13422/j.cnki.syfjx.2015090014.
Investigation of Polymer Materials and Optimization of Preparation Process of Puerarin Sustained-release Microspheres
Objective: To optimize polymer materials and preparation process of puerarin sustained-release microspheres. Method: The microspheres were prepared by emulsion solvent evaporation method.Taking composite score of encapsulation efficiency
drug loading and yield as index
polymer materials and formulation process were optimized by orthogonal design.The microspheres were characterized by different techniques
such as scanning electron microscopy (SEM)
thermogravimetric analysis (TGA)
differential scanning calorimetry (DSC)
X-ray diffraction (XRD). Result: Optimum polymer material of puerarin sustained-release microspheres was polylactic acid (PLA)
optimum preparation parameters were as follows:dosage of 37.5 mg
PLA of 80 mg
polyvinyl alcohol (PVA) of 0.5%.Surface of puerarin sustained-release microspheres was smooth and round without adhesions
average particle size was 104.3 μm
drug loading was (26.20±2.24)%
encapsulation efficiency was (68.92±1.88)%
yield was (83.97±2.55)%.TGA
DSC and XRD were indicated changes in physical form of molecular spatial relationship of copolymer and puerarin in the microspheres. Conclusion: Puerarin sustained-release microspheres can be successfully prepared by emulsion solvent evaporation method
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