Objective: To observe the effect of Bixie Chubi Tang (BXCBT) on reducing serum uric acid (SUA)

anti-inflammation and analgesia

and to discuss its mechanism. Method: The 32 Kunming mice were randomly divided into four groups:the normal group

the model group

the BXCBT group (20.9 g·kg-1)

and the llopurinol group (40 mg·kg-1). The mouse hyperuricemia model were induced in mice by intraperitoneally injecting allantoxanic acid potassium of 300 mg·kg-1. The levels of SUA and xanthine oxidase (XOD) were detected. The anti-inflammatory and antalgic effect was observed on the writhing test caused by glacial acetic acid and ear swelling caused by dimethylbenzene in mice. Both two experiments included the model group

the BXCBT group (20.9 g·kg-1) and the allopurinol group of 10 mice each. In another experiment

the acute gouty arthritis (AGA) model of mice was established by uric acid sodium salt. The 32 mice were randomly divided into the normal group

the model group

the BXCBT group (20.9 g·kg-1) and the indomethacin group (2 mg·kg-1). The levels of interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) were detected

and the anti-inflammatory effects and possible mechanisms were analyzed. Result: Compared with the normal group

the levels of SUA and XOD increased

the levels of IL-1β and TNF-α increased in the model groups (P <0.05

P <0.01). Compared with model group

levels of SUA and XOD decreased

the writhing times decreased

the mouse ear swelling and ankle swelling improved

and the levels of IL-1β and TNF-α decreased in the BXCBT group (P <0.05

P <0.01). Conclusion: BXCBT has an effect on reducing SUA in mice

and the mechanism may be related to inhibiting the expression of XOD. It also has an effect on inflammation and pain

and the mechanism may be related to inhibiting the levels of IL-1β and TNF-α.