Effects of Total Flavonoids of  on Adjuvant Induced Arthritis in Rats

WEI Xian; LI Zhen-zhong; HUANG Zu-liang

doi:10.13422/j.cnki.syfjx.2015090145

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Effects of Total Flavonoids of on Adjuvant Induced Arthritis in Rats

更新时间：2024-01-04

- Effects of Total Flavonoids of on Adjuvant Induced Arthritis in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 9, Pages: 145-149(2015)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2015090145
  CLC： R285.5
- Published：2015
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WEI Xian, LI Zhen-zhong, HUANG Zu-liang. Effects of Total Flavonoids of on Adjuvant Induced Arthritis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(9): 145-149.
DOI：

WEI Xian, LI Zhen-zhong, HUANG Zu-liang. Effects of Total Flavonoids of on Adjuvant Induced Arthritis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(9): 145-149. DOI： 10.13422/j.cnki.syfjx.2015090145.

摘要

目的: 观察五色梅总黄酮对风湿性关节炎的治疗作用. 方法: 采用完全弗氏佐剂(CFA)诱导关节炎大鼠模型

设正常组

模型组

阳性药地塞米松组(0.15 mg·kg-1)

五色梅总黄酮高、低剂量组(100

25 mg·kg-1).ig给药各组每天1次

连续16 d

观察造模后第3

24天大鼠足跖肿胀率及关节炎指数

测定大鼠炎性组织液和血清中的白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α) 的水平.小鼠二甲苯耳廓肿胀法和大鼠棉球肉芽肿法观察五色梅总黄酮的抗炎作用;小鼠热板法和醋酸扭体法观察五色梅总黄酮的镇痛作用. 结果: 与模型组比较

五色梅总黄酮100 mg·kg-1剂量组能降低佐剂性关节炎大鼠足肿胀率并降低关节炎指数(P <0.05)

并能降低佐剂性关节炎大鼠炎性组织液和血清中IL-1β

TNF-α水平(P <0.05);五色梅总黄酮140

70 mg·kg-1剂量组均能显著抑制二甲苯所致小鼠耳廓肿胀程度

100 mg·kg-1剂量组能显著抑制大鼠棉球肉芽组织质量(P< 0.05

P< 0.01);五色梅总黄酮140

70 mg·kg-1剂量组均能显著减少醋酸引起小鼠的扭体反应次数和增加小鼠热板痛阈值(P <0.05). 结论: 五色梅总黄酮有效改善类风湿性关节炎大鼠关节炎症状

同时具有显著的抗炎镇痛作用

其机制可能与降低炎性组织液和血清中IL-1β

TNF-α水平有关.

Abstract

Objective: To observe the effect and mechanism of total flavonoids of Lantana camara on rheumatoid arthritis(RA)in rats. Method: After establishing rat Freund's adjurant arthritis(AA) model

rats with AA were divided into four groups

model group

dexamethasone group(0.15 mg·kg-1) and total flavonoids of L.camara group(100

25 mg·kg-1).The total flavonoids of L.camara group were given for 16 days. The effects of total flavonoids of L.camara on anti-arthritic were studied through observing the changes of paw swelling

arthritis index at day 3

21 and 24

and levels of interleukin 1β(IL-1β) and tumor necrosis factor α(TNF-α)after medication.Anti-inflammatory activity was studied by mice auricular swelling test induced by xylene and rat inflammation model induced by planted cotton ball in axillary

and acetic acid-induced writhing and hot-plate test in mice were used to study the analgesic activity. Result: Compared with models

the total flavonoids of L.camara could inhibit paw edema and arthritis index in RA rats significantly(P <0.05)

and the levels of serum IL-1β and TNF-α showed a marked decrease (P <0.05).The total flavonoids of L.camara could inhibit the mice ear edema induced by xylene

and could also decrease the weight of cotton ball granuloma. The total flavonoids of L.camara could increase the pain threshold value of the mice on the hot plate

and decrease the number of writhing in mice flowing ip administration of acetic acid. Conclusion: The total flavonoids of L.camara could ameliorate rheumatoid arthritis in RA rats

and have a good anti-inflammatory and analgesic action

and its effect has a close relation with the level of IL-1β and TNF-α in RA rats.

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Related Institution

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Henan University of Chinese Medicine

Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-yao

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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