It was widely accepted

in the present studies on the exact pathogenesis of anxiety disorders

that there is injury of hippocampal neurons in brain. Overseas studies indicate that injury play an important role in the regulation of protein phosphatase 2A (protein phosphatase 2A

PP2A) and the expression of α-synuclein (α-synuclein). Therefore

we consider that the change in the activity of PP2A may induce the abnormal expression of α-syn

causing relative changes in neurons;so the phosphorylation/dephosphorylation of 129 points α-syn protein C-terminal9 might be caused through regulating the activity of PP2A

then GR activity against neuronal apoptosis are further regulated

to repair damaged hippocampus

then to work in the anti-anxiety disorder. This paper reviews the research progress on the protein phosphatase 2A

α-synuclein in the molecular mechanisms of anxiety disorders and the progress on experimental study of the mechanism of Chinese medicine compound Danzhi Xiaoyao San in the treatment of anxiety disorders in recent years.