GUO Hui-ling, GUO San-bao, ZHAO Xiao-juan, et al. Optimization of Prepration Process of Apocyni Veneti Folium Sustained-release Dropping Pills by Box-Behnken Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(10): 19-22.
DOI:
GUO Hui-ling, GUO San-bao, ZHAO Xiao-juan, et al. Optimization of Prepration Process of Apocyni Veneti Folium Sustained-release Dropping Pills by Box-Behnken Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(10): 19-22. DOI: 10.13422/j.cnki.syfjx.2015100019.
Optimization of Prepration Process of Apocyni Veneti Folium Sustained-release Dropping Pills by Box-Behnken Design-response Surface Methodology
Objective: To optimize preparation process of Apocyni Veneti Folium sustained-release dropping pills for providing a reference for industrial production of this preparation. Method: Sustained-release dropping pills were prepared by solid dispersion method.On the basis of single factor tests
taking ratio of substrate to drug
ratio of polyethylene glycol 6000 (PEG6000) to stearic acid and material temperature as dependent variables
Box-Behnken design was conducted to optimize prepration process with appearance quality
pill weight difference and in vitro release as indexes. Result: Optimal preparation process was as follows:substrate-drug(6.77: 1)
PEG6000-stearic acid (4.87: 1)
material temperature of 66 ℃.Bias between the observed value and the predicted value were less than 3.0%. Conclusion: Box-Behnken surface response design is suitable for optimizing prepration process of Apocyni Veneti Folium sustained-release dropping pills with good predictability.These prepared dropping pills have good appearance quality
small weight difference and sustained-release effect.