Objective: To find out the changes before and after the material basis of compatibility

and to discover the interaction among the process of compound mixing

through established the HPLC fingerprints of Yinqiao San(YQS) and Jun(J)

Chen(C)

Zuo(Z)

Shi(S). Then investigated the relationship of compound compatibility of YQS on the whole. Method: The chromatographic condition was:Ultimate 3000 XRS ultra fast liquid chromatography

thermo C18(4.6 mm×250 mm

5 μm) column

methanol-0.05% phosphoric acid water as the mobile phase gradient elution

the detection wavelength was 237 nm and flow rate was 1 mL · min-1. Researched and established the HPLC fingerprint of YQS and other groups

then used the fingerprint processing software to analys the data of each group HPLC fingerprint. Result: The similarities from high to low between YQS and other compatibility groups are:J

C

S (0.981)>J

C(0.959)>J

C

Z(0.953)>J

Z

S (0.806). The similarities from high to low between YQS and J

C

Z

S are:J(0.749)>C(0.573)>Z(0.136)>S(0.104). Compared with the single decoction added

the fingerprint areas of YQS decoction had 14 peaks decreased and 63 peaks increased. Conclusion: J and C were the main source of material basis of YQS. In this paper

from the perspective of the material basis composition

the datas analysed how important of J

C

Z and S in the whole prescription.This result made the traditional interpretation of prescription more persuasive.