XIONG Shan, LI Jing-lai, WANG Xiao-ying, et al. Study on Targeting Ddistribution of Morroniside in Rat Brain[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(10): 87-90.
DOI:
XIONG Shan, LI Jing-lai, WANG Xiao-ying, et al. Study on Targeting Ddistribution of Morroniside in Rat Brain[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(10): 87-90. DOI: 10.13422/j.cnki.syfjx.2015100087.
Study on Targeting Ddistribution of Morroniside in Rat Brain
Objective: The aim of this study was to investigate the steady-state brain-plasma concentration ratio of morroniside in focal cerebral ischemia-reperfusion model rats. Method: The in vivo rat model was established. The middle cerebral artery occlusion was induced by the intraluminal filament technique. The concentrations of morroniside in the plasma and brain of rats were determined from normal control group
sham-operated group and focal cerebral ischemia- reperfusion model group
and the blood brain partitioning(lg BB) of morroniside was calculated while the plasma concentration of morroniside was in the steady-state via intravenous drip (55 min) by LC-MS/MS. Result: Morroniside almost could not pass through the blood brain barrier in normal rats. The lg BB of morroniside in the left and right brain of focal cerebral ischemia-reperfusion model rats were (1.36±0.44) and (2.26±0.13)
respectively
which were significantly higher than the normal control group and sham-operated group rats. Conclusion: The results demonstrated that morroniside could pass through the blood brain barrier in rats in focal cerebral ischemia-reperfusion model group more easily than normal control and sham-operated group.
Discussion for Quality Control of Chinese Patent Drugs from Quality Difference Among Different Dosage Forms of Liuwei Dihuang Preparations
Analysis on Contents of Loganin and Morroniside in Cultivated and Wild Fructus Corni
Simultaneous Determination of Morroniside and Loganin in Rats Plasma from Dispersible Tablets of Total Glucosides from by HPLC
Comparison of Enrichment Effect of Iridoid Glycosides from by Different Macroporous Resins
Investigation of Dissolution of Three Components in Liuwei Dihuang Gantang Tablets
Related Author
Hong YI
Li-hua YAN
Wen-wen ZHANG
Yu YAN
Qin SI
Xiao-qian LIU
Zhi-min WANG
Xia-xia FENG
Related Institution
College of Pharmacy, Shaanxi University of Chinese Medicine
National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences