Objective: The aim of this article was to study the pharmacokinetics of chrysophanol solid dispersion in rats. Method: Male SD rat (n=20) were randomly divided into two groups (n=10). The rats were administrated chrysophanol and chrysophanol solid dispersions respectively

the two groups were fed in the same dosage of chrysophanol (40 mg · kg-1). The concentration of chrysophanol in plasma were determined by high performance liquid chromatography (HPLC).The software of DAS1.0 was used to process the pharmacokinetic parameters. Result: The concentration-time profiles of chrysophanol and its solid dispersions conformed to two-compartment model. Their AUC

Cmax

and Tmax in chrysophanol group were (226.7±18.62) μg · h-1 · mL-1

(1.37±0.14) mg · L-1 and(68.99±5.24) h

respectively

while in chrysophanol solid dispersions group they were (1 210.0±56.32) μg · h-1 · mL-1

(8.17±0.94) mg · L-1 and(38.42±2.78) h

respectively. Statistical results indicated that both of AUC and Cmax showed significant difference in the two groups (P<0.05). Conclusion: The preparation of chrysophanol solid dispersion with polyethylene glycol as the carrier increases the bioavailability of chrysophanol in rats.