HUANG Lei, ZHANG Wen, SUN Shuai-jun, et al. Protective Effects of Buxin Ruanmai Granules on Acute Myocardial Ischemia in Anaesthetized Dogs[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(10): 99-103.
DOI:
HUANG Lei, ZHANG Wen, SUN Shuai-jun, et al. Protective Effects of Buxin Ruanmai Granules on Acute Myocardial Ischemia in Anaesthetized Dogs[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(10): 99-103. DOI: 10.13422/j.cnki.syfjx.2015100099.
Protective Effects of Buxin Ruanmai Granules on Acute Myocardial Ischemia in Anaesthetized Dogs
Objective: To observe the protective effects of Buxin Ruanmai granules on acute myocardial infarction in anaesthetized dogs. Method: A total of 36 dogs were divided into the Buxin Ruanmai granules high dose
middle dose
low dose groups
Xinyuan capsule group
model group and sham group.The hemodynamics and myocardial oxygen metabolism
the myocardial infarct size
and the changes of the enzymes in serum were determined in the acute myocardial infarction model induced by ligation of left anterior descending (LAD) in the anaesthetized dogs;nitro blue tetrazolium (NBT) staining was used to observe infarct size;blood gas analyzer was used to measure oxygen content. Result: Except for increasing coronary blood flow
the cardium oxygen consumption
myocardial infarct size
the activity of serum creatine kinase (CK) and lactate dehydrogenase (LDH) were decreased in acute myocardial infarction dogs treated with the Buxin Ruanmai granules(P<0.05
P<0.01). Buxin Ruanmai high dose had significant difference(P<0.01). Conclusion: The Buxin Ruanmai granules have protective effects on myocardial ischemia in anaesthetized dogs.