Objective: To investigate the effect of Cassia nomame on obesity and insulin resistance in high-fat diet-induced C57BL/6J Mice. Method: The experimental animals were randomly divided into six groups:the normal group

the model group

the low-

middle- and high-dose Cassia nomame groups(0.1

0.3

0.9 g ·kg-1)

and the rosiglitazone group(0.75 mg ·kg-1) of 15 rats each. All mice received intragastric administration of the corresponding medicines

the body weight of mice was measured every week. After 12-hour fast but water-drinking

the fasting plasma glucose (FBG) of mice was tested at the end of the eighth week. After all experimental animals were executed

body length was measured

the adipose tissue around stomach

testis and kidney were weighed

and the stomach adipose tissue was stained by HE staining. Fasting insulin (FINS) was measured and the insulin resistance index (IRI) was calculated. The levels of total cholesterol (TCH)

triglyceride (TG)

interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in serum were measured. Result: Compared with normal diet group

the body weight

the levels of FBG

FINS

TCH

TG

IL-6 and TNF-α increased in the model group (P<0.01). Compared with the model group

the body weight

and the levels of FBG

FINS

TCH

TG

IL-6 and TNF-α decreased in the C. nomame group (P<0.05

P<0.01). HE staining showed that the fat content and cell volume decreased in the C. nomame group. Conclusion: Cassia nomame could effectively inhibit obesity and insulin resistance in high-fat diet-induced C57BL/6J mice.