Objective: To observe the efficacy and safety of Bushen Qiangdu Zhilou decoction combined du-moxibustion in treating ankylosing spondylitis of kidney deficiency and cold syndrome. Method: Fourty patients were selected from the Rheumatism clinic and randomly divided into the combination group (traditional Chinese medicine combined du-moxibustion treatment) and the control group (Chinese medicine treatment). All patients received 12 weeks of treatment. Before and after treatment

the integral score of Chinese medical syndrome

the Bath ankylosing spondylitis activity index (BASDAI)

the Bath ankylosing spondylitis functional index (BASFI)

patients' overall evaluation (PGA)

spinal pain VAS

refers to the distance

pillow wall distance

thoracic mobility

lumbar motion changes (Schober test)

blood sedimentation (ESR) and c-reactive protein (CRP) level were measured. At the same time

the adverse reactions like liver function test

kidney function test

blood routine examination were recorded during the treatment. Result: The total effectiveness of symptomatic efficacy in the combination group was 94.4%

which was superior to that of 70% in the control group (P<0.05). The cases of ASAS20

ASAS50 and BASDAI50 in the combination group were more than those in the control group (P<0.05).The improvements of the refers to the distance spinal pain

spinal inflammation

the BASDAI

score of Chinese medical symptom were better in the treatment group as compared with the control group (P<0.05). Levels of ESR and CRP decreased in the two groups after treatment (P<0.05

P<0.01)

but there was no statistically significant difference between the two groups. Unusual liver and kidney function

and blood routine tests were found during the treatment. However

no serious adverse reactions were found. Conclusion: Bushen Qiangdu Zhilou decoction combined du-moxibustion could enhance the clinical curative effect and safety greatly in treating ankylosing spondylitis

and it has wide application prospect.