Comparison of Effects of Different Ultrafiltration Membrane Modules on Decarburization Fluid of Reduning Injection

ZHU Ming-yan; LING Ya; FAN Qing-long; SHI Yun-long; JIN Zi-xiang; XIAO Wei

doi:10.13422/j.cnki.syfjx.2015110020

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Comparison of Effects of Different Ultrafiltration Membrane Modules on Decarburization Fluid of Reduning Injection

更新时间：2024-01-04

- Comparison of Effects of Different Ultrafiltration Membrane Modules on Decarburization Fluid of Reduning Injection
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 11, Pages: 20-23(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015110020
  CLC： R283.6
- Published：2015
- 稿件说明：
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ZHU Ming-yan, LING Ya, FAN Qing-long, et al. Comparison of Effects of Different Ultrafiltration Membrane Modules on Decarburization Fluid of Reduning Injection[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(11): 20-23.
DOI：

ZHU Ming-yan, LING Ya, FAN Qing-long, et al. Comparison of Effects of Different Ultrafiltration Membrane Modules on Decarburization Fluid of Reduning Injection[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(11): 20-23. DOI： 10.13422/j.cnki.syfjx.2015110020.

摘要

目的: 以热毒宁注射液脱炭液为研究对象

比较3种膜组件对热毒宁注射液膜过滤的适用性. 方法: 选取中空纤维、板式、卷式3种膜组件进行超滤

以膜通量、超滤前后指标性成分(栀子苷、绿原酸)转移率、指纹图谱相似度、固含物减少率、蛋白质、药液色泽、草酸盐、树脂为评价指标

比较3种膜组件对热毒宁注射液脱炭液的膜过滤效果. 结果: 3种膜组件对同一药液体系适用性存在差异

板式膜组件膜通量最大

中空纤维膜组件膜通量最小.中空纤维、板式、卷式膜组件的栀子苷透过率分别为87.53%

91.76%

89.41%

绿原酸透过率分别为86.46%

91.23%

89.47%

指纹图谱相似度分别为0.992

0.995

0.999

固含物减少率分别为21.35%

18.64%

17.53%

药液色泽由超滤前的8号分别变为3

5号. 结论: 中空纤维、板式膜在固含物减少率及提高澄明度方面较卷式膜有优势.3种膜组件均适合热毒宁注射液脱炭液的超滤

其中以板式膜为最佳.

Abstract

Objective: Taking decarburization fluid of Reduning injection as research object

to compare applicability of three kinds of membrane modules for membrane filtration of Reduning injection. Method: Hollow fibre

plate and roll type of membrane module was selected for ultrafiltration

taking membrane flux

transfer rates of index ingredients (gardenoside and chlorogenic acid) before and after ultrafiltration

fingerprint similarity

solid content decrement

protein

color comparison

oxalic acid salt and resin as indexes

membrane filtration effect of 3 kinds of membrane modules on Reduning injection was compared. Result: Three kinds of membrane modules existed differences on applicability of the same liquid system

membrane flux of plate type of membrane module was maximum

hollow fiber membrane module was minimum.Transmittances of gardenoside with hollow fiber

plate

roll type of membrane module were 87.53%

91.76% and 89.41%

transmittances of chlorogenic acid were 86.46%

91.23% and 89.47%

fingerprint similarity were 0.992

0.995 and 0.999

reduction rates of solid content were 21.35%

18.64% and 17.53%

liquid color from 8 into 3

4 and 5

respectively. Conclusion: In reduction rates of solid content and degree of clarity improvement

hollow fiber and plate type of membranes have advantages by camparing with roll type of membrane.Three types of membrane modules are suitable for ultrafiltration of decarburization fluid of Reduning injection

which best plate type of membrane.

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Related Institution

The Second Clinical College of Guangzhou University of Chinese Medicine

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Institute of Traditional Chinese Medicine（TCM），Shanghai University of TCM

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