Analysis Method of Alpha Asarone  Gel

ZE Wei-wei; ZHANG Yong-ping; XU Jian; YANG Chang-fu; LIU Ming

doi:10.13422/j.cnki.syfjx.2015110042

您当前的位置：

首页 >

文章列表页 >

Analysis Method of Alpha Asarone Gel

更新时间：2024-01-04

- Analysis Method of Alpha Asarone Gel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 11, Pages: 42-45(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015110042
  CLC： R286.0
- Published：2015
- 稿件说明：
移动端阅览
ZE Wei-wei, ZHANG Yong-ping, XU Jian, et al. Analysis Method of Alpha Asarone Gel [J]. Chinese journal of experimental traditional medical formulae, 2015, 21(11): 42-45.
DOI：

ZE Wei-wei, ZHANG Yong-ping, XU Jian, et al. Analysis Method of Alpha Asarone Gel [J]. Chinese journal of experimental traditional medical formulae, 2015, 21(11): 42-45. DOI： 10.13422/j.cnki.syfjx.2015110042.

摘要

目的: 建立 α-细辛脑原位凝胶含量测定和体外释放度测定方法. 方法: 采用HPLC法

SHIM-PACK VP-ODS色谱柱(4.6 mm×250 mm

5 μm)

流动相甲醇-水(75:25)

检测波长258 nm

采用磷酸盐缓冲溶液(pH 7.4)作为释放液. 结果: 含量测定中 α-细辛脑在10.4~104 mg·L-1与峰面积具有良好的线性关系(r=1)

平均回收率100.6%

RSD 2.2%.体外释放度试验中 α-细辛脑在2.06~82.4 mg·L-1线性较好(r=0.999 9)

平均回收率95.83%

RSD 2.5%. 结论: 建立的分析方法具有专属性好、准确和可靠的特点

可为后续研究奠定基础.

Abstract

Objective: Set up the analysis method of alpha asarone in situ gel and the analysis method of it's in vitro release. Method: HPLC instrument with SHIM-PACK VP-ODS column(4.6 mm×250 mm

5 μm)was used.The mobile phase consisted of methanol-water (75 : 25)

The wavelength for detection was 258 nm. And using pH 7.4 slightly PBS as release liquid. Result: The liner range of alpha asarone was 10.4-104 mg·L-1(r=1).The average recovery was 100.6%

RSD was 2.19% in the determination of experiment.The liner range of alpha asarone was 2.06-82.4 mg·L-1(r=0.999 9).The average recovery was 95.83%

RSD was 2.5% in the in vitro release experiment. Conclusion: The method is exclusive

accurate and reliable.And it can lay the foundation for follow-up study.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Preparation and Evaluation of Artemether Oral Microemulsion- Gel

Optimization of Formulation of -Asarone Nanoparticles Gel and Investigation of Its Release Properties

Advances in the Studies on In Situ Gels by Mucosal Drug Delivery

Related Author

PENG Xin-jun2

TONG Yan 1

WANG Jin-yu1

CHEN Liang-mian 1

TANG Hua-zheng

CAI Zheng

YANG Zhao-xiang

Related Institution

Institute of Chinese Materia Medica,China Academy of Chinese Medicinal Sciences

College of Pharmacy,Hunan University of Traditional Chinese Medicine

中国中医科学院中药研究所湖南中医药大学药学院

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰