Objective: The aim of this study was to explore the influence of blood lipids

inflammatory factors and endothelial function in patients with acute coronary syndrome after percutaneous coronary intervention(PCI) by Xueshuantong injection. Method: In this study

eighty acute coronary syndrome patients treated by PCI between December 2012 and June 2014 were included

and according to the random numbers

they were divided into treatment group and control group

with 40 cases in each group. The control group was given conventional drug treatment

on the basis of the control group

the treatment group was given Xueshuantong injection for treatment. The lipid level

inflammation factors

endothelial function and adverse reactions before and after surgery were compared. Result: In treatment group

there was no case with thrombolysis in myocardial infarction(TIMI) grade of level 0

0 case in level Ⅰ

6 cases in level Ⅱ

34 cases in level Ⅲ.In control group

there was 0 case in level 0

0 cases in level Ⅰ

15 cases in level Ⅱ

25 cases in level Ⅲ

with significant difference compared to treatment group(P <0.05).After drug intervention for one month after sugery

the levels of total cholesterol(TC)

triglyceride(TG)

low density lipoprotein-cholesterol (LDL-C) in both two groups were decreased

while the level of high density lipoprotein-cholesterol (HDL-C) was increased

with significance difference (P <0.05). The levels of TC

TG

LDL-C in treatment group was lower than those in control group

the level of HDL-C was higher than that in control group

with significant difference (P <0.05). Preoperative high-sensitivity C-reactive protein(hs-CRP)

interleukin-6(IL-6)

endothelin(ET)

fibrinogen(Fg)

von willebrand factor(vWF) one day after surgery were all increased

but with no significant difference between two groups. The hs-CRP

IL-6

ET

Fg

vWF one month after surgery in two groups were decreased with significant difference (P <0.05)

and the hs-CRP

IL-6

ET

Fg

vWF one month after surgery in treatment group were lower than those of control group with statistical significance (P <0.05). Within a month after surgery

in control group there were 4 cases for angina pectoris

1 case for myocardial infarction

the incidence of cardiac event was 12.5%;while in treatment group there were 2 cases for angina pectoris

none for myocardial infarction

the incidence of cardiac event was 5.0%

with no statistically significant differences between two groups. Conclusion: Xueshuantong injection can control postoperative blood lipids in patients with acute coronary syndromes

inhibit inflammation

improve endothelial function

and reduce postoperative cardiac events.