Objective: To observe the protective effect of Bushen Jianpi Jiangzhuo decoction for oral administration/enema in treating patients with chronic kidney disease stage 4 (CKD 4). Method: One hundred patients with CKD 4 were randomly divided into the control group (48 cases) and the observation group (52 cases) by a random number table. Patients in the control group received 100 mg losartan potassium tablets once daily. Based on the treatment of the control group

patients in the observation group added Bushen Jianpi Jiangzhuo decoction for oral administration/enema. All patients in both two groups received 6 months of treatment. Before and after treatment

24-hour urine protein quantitation (24-h Upr)

urea nitrogen (BUN) and serum creatinine (SCr) were detected. Epidermal growth factor receptor (eGFR) was calculated. The main symptoms

signs and the end points of response rate were recorded. Health related quality of life (SF-36) was evaluated. Result: The total clinical efficiency in the observation group was 82.69%

which was superior to that of 64.58% in the control group (P <0.05). After treatment

24-h Upr in the observation group was lower than that in the control group (P <0.01). BUN and SCr increased persistently (P <0.05

P <0.01)

eGFR decreased (P <0.01) in the control group. BUN and eGFR decreased (P <0.01)

and SCr increased in the observation group. Levels of UN and SCr were lower than those in the control group

and level of eGFR was higher than that in the control group (P <0.01). At the third and sixth month after treatment

scores of the main symptoms and signs in the observation group were lower than those in the control group (P <0.01). The end point of response rate in the observation group was 23.08%

which was lower than that of 43.75% in the control group (P <0.05). After treatment

scores of general health

social function

vigour of life and mental health in the observation group were higher than those in the control group (P <0.05). Conclusion: Based on the conventional Western treatment

Bushen Jianpi Jiangzhuo decoction for oral administration/enema could protect the renal function and delay condition progress of patients with CKD 4.Moreover

it could ameliorate symptoms

and improve patients' quality of life. Its efficacy is superior to using Western treatment alone.