Objective: The study aimed to systematically review the clinical efficacy and safety of Yanhuning combined with interferon for curing the hand-foot-mouth disease (HFMD). Method: Using the Cochrane system evaluation method

the retrieval of the Cochrane Library

EMbase

PubMed

CBM

CNKI and Wanfang Data database

a randomized controlled trial of finding out about the Yanhuning and interferon in the treatment of hand foot and mouth disease (RCT)

were searched from inception to 2014 September; manual search of relevant conference literature

language and English Chinese limit; 2 reviewers independently screened according to the inclusion and exclusion criteria

extracted data and literature quality evaluation

Meta-analysis was carried out using RevMan 5.2 software. Result: There were 18 studies (2 080 cases) included. The results of Meta-analysis showed that compared to Yanhuning alone

Yanhuning combined with interferon increased the total treatment efficiency of HFMD [OR=3.72

95%CI(2.26

6.11)

P <0.000 01]

with shorter cooling time [MD=-0.74

95%CI(-1.05

-0.44)

P <0.000 01]

simplex regression time[MD=-1.17

95%CI(-1.39

-0.96)

P <0.000 01]

and healing time[MD=-0.83

95%CI(-0.90

-0.76)

P <0.000 01]. Compared to interferon alone

Yanhuning combined with interferon increased the total treatment efficiency of HFMD [OR=3.95

95%CI(2.03

7.69)

P <0.000 1]

with shorter cooling time[MD=-0.60

95%CI(-0.76

-0.45)

P<0.000 01]

simplex regression time[MD=-0.98

95%CI(-1.12

-0.84)

P <0.000 01]

healing time [MD=-0.94

95%CI(-1.23

-0.65)

P <0.000 01]. Conclusion: The current study showed that Yanhuning combined with interferon are efficacious in the treatment of HFMD than Yanhuning injection alone or interferon alone.