ZHU Chun-yun, ZHANG Di-dan, ZHANG Yong-tai, et al. Formulation Optimization of Tripterygium Glycosides Loaded Gel Poste[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(12): 16-18.
DOI:
ZHU Chun-yun, ZHANG Di-dan, ZHANG Yong-tai, et al. Formulation Optimization of Tripterygium Glycosides Loaded Gel Poste[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(12): 16-18. DOI: 10.13422/j.cnki.syfjx.2015120016.
Formulation Optimization of Tripterygium Glycosides Loaded Gel Poste
Objective: To optimize the formulation of tripterygium glycosides loaded gel paste. Method: With the overall weighted score of initial adhesion
peel strength and sensory (appearance
skin adhesive ability and residue of gel paste on the skin after peeling off) as index
the influence of contents of dihydroxyaluminum aminoacetate
glycerol
tartaric acid povidone K90 on characteristics of formulation were evaluated by undertaking experiments according to orthogonal design. Result: All the evaluated factors
especially the content of glycerol as well as dihydroxyaluminum aminoacetate
showed significant influence on characteristics of formulation. In the optimum formulation
the weight ratio of povidone K90 to dihydroxyaluminum aminoacetate
glycerol and tartaric acid was 1.50: 0.15: 30.0: 0.15.The weighted scores of initial adhesion
peel strength and sensory of the optimum formulation were 48.89
19.43 and 28.67
respectively.The prepared tripterygium glycosides loaded gel paste was uniform in size and color
exhibited good skin adhesive ability and no residue on skin after the peeling off of the gel paste. Conclusion: By using orthogonal experimental design
the formulation of glycosides loaded gel paste might be optimized effectively with reduced test times
and these factors influencing characteristics of formulation might be evaluated comprehensively.This optimized formulation is feasible and reproducible.