Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used

JIANG Nan; PU Ji; ZHANG Bing-bing; ZHANG Wen-shun; MA Xian-de; SHI Yan

doi:10.13422/j.cnki.syfjx.2015120095

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Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used

更新时间：2024-01-04

- Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 12, Pages: 95-98(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015120095
  CLC： R285.5
- Published：2015
- 稿件说明：
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JIANG Nan, PU Ji, ZHANG Bing-bing, et al. Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(12): 95-98.
DOI：

JIANG Nan, PU Ji, ZHANG Bing-bing, et al. Syndrome Identification of Abnormal Glucose Metabolism in Metabolic Syndrome Rat Based on Syndrome Detecting from Recipe Used[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(12): 95-98. DOI： 10.13422/j.cnki.syfjx.2015120095.

摘要

目的: 在糖代谢异常(IGR)的代谢综合征大鼠中使用“以方测证法”研究其中医证型。方法: 在建立糖代谢异常的代谢综合征(MS)大鼠模型后

用随机对照表法按血糖高低随机分为MS组

六君子汤(LJZ)组

参芪地黄汤(SQDH)组

肾气丸(SQ)组。用3个方剂:LJZ组 2.5 g·kg-1·d-1

SQDH组25 g·kg-1·d-1

SQ组9.5 g·kg-1·d-1

于造模12周后ig给药

每天1次

持续3周。于12周和15周末

检测其体重

血压

空腹血糖(FBG)

甘油三酯(TG)

高密度脂蛋白胆固醇(HDL-C)

空腹胰岛素(FIN)

胰岛素抵抗指数(HOMA-IR)。结果: 第15周时

与正常组比较模型组体重

血压

FBG

FINS和HOMA-IR显著升高(P<0.05

P<0.01)

HDL-C显著降低;与模型组比较3个方剂干预各组体重

血压

FBG

HDL-C均无显著差异

FINS和HOMA-IR显著降低(P<0.01)。结论: 在IGR的MS大鼠药物干预后胰岛素水平和HOMA-IR显著降低

根据以方测证法

说明脾虚痰湿证、阴阳两虚证、气阴两虚证在本模型中可同时存在

是一个虚实夹杂证型。

Abstract

Objective: To explore TCM syndromes in abnormal glucose metabolism syndrome(MS) rats based on syndrome detecting from recipe used. Method: After the establishment of the MS rat model of abnormal

according to sugar of blood level

rats were divided into MS group

group A

group B

group C. Liujunzi Tang(A

2.5 g·kg-1)

Shenqi Dihuang Tang(B

25 g·kg-1)

Shenqi Wan(C

0.5 g·kg-1) were given.At 12 and 15 weeks

the weight

blood pressure

fasting blood glucose(FBG)

triglycerides(TG)

high density lipoprotein(HDL-C) and fasting insulin (FIN) levels were measured. Result: Compared with the model group

in A

C group

body weight

blood pressure

FBG

HDL-C had no significant forward difference

in A

C group FIN and insulin resistance index(HOMA-IR) was significantly lowered(P<0.01). Conclusion: Abnormal glucose metabolism with metabolic syndrome in rats after intervention significantly improved insulin levels

according to the measured in square card method

shows that the spleen with phlegm

Yin and Yang dificiency syndrome in two

two Qi and Yin dificiency syndrome can exist at the same time

which is a deficiency syndrome type.

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Related Institution

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