Impact of Tangshenning to Level of HGF,CysC and TGF- in Patients with Two Deficiency of Qi and Yin and Blood Stasis Type of Early Diabetic Nephropathy

YAO Yu-hong; GUO Li-ge

doi:10.13422/j.cnki.syfjx.2015120139

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Impact of Tangshenning to Level of HGF,CysC and TGF- in Patients with Two Deficiency of Qi and Yin and Blood Stasis Type of Early Diabetic Nephropathy

更新时间：2024-01-04

- Impact of Tangshenning to Level of HGF,CysC and TGF- in Patients with Two Deficiency of Qi and Yin and Blood Stasis Type of Early Diabetic Nephropathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 12, Pages: 139-142(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015120139
  CLC： R259
- Published：2015
- 稿件说明：
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YAO Yu-hong, GUO Li-ge. Impact of Tangshenning to Level of HGF,CysC and TGF- in Patients with Two Deficiency of Qi and Yin and Blood Stasis Type of Early Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(12): 139-142.
DOI：

YAO Yu-hong, GUO Li-ge. Impact of Tangshenning to Level of HGF,CysC and TGF- in Patients with Two Deficiency of Qi and Yin and Blood Stasis Type of Early Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(12): 139-142. DOI： 10.13422/j.cnki.syfjx.2015120139.

摘要

目的: 探讨糖肾宁对气阴两虚夹瘀型早期糖尿病肾病患者肝细胞生长因子(HGF)

胱抑素C(CysC)和转化生长因子β1(TGF-β1)水平的影响分析

为临床诊断治疗提供参考。方法: 将90例气阴两虚夹瘀型早期糖尿病肾病患者按照随机数字表法分为对照组(n=45)和观察组(n=45);对照组给予洛丁新治疗

治疗组在对照组治疗基础上服用中药汤剂糖肾宁;观察两组的疗效

TGF-β1

尿白蛋白排泄率(UAER)

同型半胱氨酸(Hcy)

CysC

HGF

血肌酐(SCr)

肌酐清除率(CCr)变化。结果: 治疗组总有效率(93.33%)显著高于对照组(75.56%)

组间有显著性差异(P<0.05);两组治疗后血清UAER

Hcy

CysC含量均显著低于治疗前

且具有显著性差异(P<0.05);治疗组治疗后血清UAER

Hcy

CysC含量显著低于对照组治疗后

且具有显著性差异(P<0.05);两组治疗后血、尿中TGF-β1含量均显著低于治疗前

且有显著性差异(P<0.05);两组血清HGF含量显著高于治疗前

且有显著性差异(P<0.05);治疗组治疗后血、尿中TGF-β1

CCr含量均显著低于对照组治疗后

且有显著性差异(P<0.05);治疗组治疗后血清HGF含量显著高于对照组治疗后

且有显著性差异(P<0.05)。结论: 糖肾宁联合西药治疗气阴两虚夹瘀型早期糖尿病肾病的疗效显著

能显著提高HGF含量

保护肾脏组织;能显著降低CysC含量

改善肾小球通透性;能显著降低TGF-β1含量

抑制肾组织纤维化。

Abstract

Objective: This study aimed to investigate the impact of Tangshenning on the levels of hepatocyte growth factor (HGF)

cystatin C(CysC) and transforming growth factor-β1(TGF-β1) in patients with two deficiency of Qi and Yin and blood stasis-typed early diabetic nephropathy

to provide reference for clinical diagnosis and treatment. Method: According to random number table method

90 cases of Qi and Yin and blood stasis-typed early diabetic nephropathy patients were randomly divided into control group (n=45) and observation group (n=45). The control group was given Luodingxin treatment

on the basis of the control group

the observation group was treated with Chinese herbal medicinal Tangshenning. The curative effects

TGF-β1

urinary albumin excretion rate (UAER)

homocysteine (Hcy)

CysC

HGF

serum creatinine (SCr)

and creatinine clearance (CCr) were observed. Result: The total effective rate in observation group (93.33%) was significantly higher than control group (75.56%)

and there were significant differences (P<0.05);levels of serum UAER

Hcy

CysC after treatment in two groups were significantly lower than before treatment

with significant difference (P<0.05);serum UAER

Hcy

CysC after treatment in observation group were significantly lower than those in control group

with significant difference (P<0.05);TGF-β1 in blood and urine after treatment were significantly lower than before treatment

with significant differences (P<0.05);level of serum HGF was higher than before treatment

with significant differences (P<0.05);TGF-β1 in blood and urine and CCr after treatment in observation group were significantly lower than the control group

qith significant differences (P<0.05);level of serum HGF after treatment in observation group was significantly higher than in control group

and thedifference was significant (P<0.05). Conclusion: The effect of Tangshenning combined with western medicine on the treatment of Qi and Yin and blood stasis-typed early diabetic nephropathy patients is significantly evident

it can significantly improve HGF to protect kidney tissue

and reduce the content of CysC to improve glomerular permeability

as well as reduce the content of TGF-β1 to inhibit cell fibrosis.

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