Objective: The aim of this study was to observe the clinical therapeutic effect and the change of life quality of Huatan Xifeng method in patients with epilepsy the method. Method: The sixty-one patients with epilesy who met the inclusion criteria were randomized divided into treatment group and control group. Both groups were treated by the routine antiepileptic drugs. The patients in treatment group received traditional Chinese medicine (TCM) soup according to the method of Huatan Xifeng

additionally. The course of treatment in both group lasted for 3 months. Clinical therapeutic effect and the change of the score of the quality of life in epilepsy-31(QOLIE-31) were compared. Result: The clinical efficacy in treatment group was 0 case as clinical recovery

4 cases as markedly effective

21 cases as effective

and 5 cases as invalid. In control group

the clinical efficacy was 0 case as clinical recovery

0 case as markedly effective

14 cases as effectiv

17 cases as invalid.The total effective rate in treatment group was 83.33%

while in control group it was 45.16%

with statistically significant difference (P<0.01).After treatment

the scores of QOLIE-31 in both group were higher than before treatment. The difference was statistically significant (P<0.01). But the difference between two groups was not statistically significant. Further analysis of each factors:in treatment group

the difference in six aspects including spiritual state

social function

cognitive function

the effect of drugs

worry to seizure and feeling of health were statistically significant (P<0.05). The difference in emotional state was not statistically significant.In control group

the difference in five aspects including spiritual state

social function

cognitive function

the effect of drugs

worry to seizure were statistically significant (P<0.05). The difference in emotional state and feeling of health was not statistically significant. In the third month

the scores of QOLIE-3 in treatment group in three aspects spiritual state

worry to seizure and feeling of health were higher than in control group. The difference was statistically significant (P<0.05). Conclusion: The TCM soup according to the method of Huatan Xifeng with routine antiepileptic drugs can ameliorates the state of the epilepsy patient

such as spirit

physical strength and sleep

and improve the quality of life in epilepsy patients.