Objective: To discuss the adjuvant effect of Hushen Kangfu decoction for assistance of hormone in treating recurrent pediatric nephrotic syndrome (PNS) disease of splenasthenic hygrosis type

and to investigate its influence on serum inflammatory factors and high blood coagulation state. Method: Ninety-six patients were randomly divided into the observation group (48 cases) and the control group (48 cases) via a digital method. Patients in the control group received hormone therapy

and patients in the observation group added Hushen Kanghu decoction. All patients in both two groups received 4 months of treatment. Levels of 24 h urine protein

total protein (TP)

albumin (ALB)

total cholesterol (TC)

triglycerides (TG)

fibrinogen (FIB)

D-dimer(D-D)

platelet aggregation rate (MPAR)

tumor necrosis factor-α (TNF-α)

hypersensitive C-reactive protein (hs-CRP) and interleukin 6 (IL-6) were detected before and after therapy. Besides

safety indicators of heart

liver and kidney were monitored. Result: The clinical curative effect in the observation group was superior to that in the control group (P<0.05). After treatment

levels of 24 h urine protein

TG and TC in the observation group were lower (P<0.01)

while standards of TP and ALB were higher (P<0.01) than those in the control group. Standard of FIB

D-D and MPAR in the observation group were inferior to those in the control group after therapy (P<0.01). Besides

levels of TNF-α

hs-CRP and IL-6 in the observation group were lower than those in the control group (P<0.01). Conclusion: The clinical curative effect of hormone assisted with Hushen Kangfu decoction was superior to using Western therapy alone in treating recurrent PNS children. Its mechanism may be related to reducing inflammation

regulating lipid metabolism

enhancing blood high condensation state.