Objective: To discuss the clinical efficacy and action mechanism of Bushen Pinggan decoction for oral and bath foot combined conventional Western medicine in treating refractory hypertension of overabundant liver-fire syndrome. Method: Ninety-three patients were randomly divided into the control group (46 cases) and the observation group (47 cases) by a random number table. Patients in the control group received 50 mg Losartan Potassium tablets once daily

10 mg Nifedipine tablets once daily and 25 mg Hydrochlorothiazide tablets twice daily based on the non-drug intervention. On the basis of the control group

patients in the observation group added Bushen Pinggan decoction for oral and bath foot. All patients in both two groups received 8 weeks of treatment. Blood pressure levels were measured before and after treatment

blood pressure success rate was recorded. Levels of nitric oxide (NO)

endothelin 1 (ET-1)

serum inhibition (Cys C) and β2 microglobulin (β2-MG) were detected. Result: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels in the observation group were lower than those in the control group (P<0.01). The blood pressure control efficacy in the observation group was better than that in the control group (P<0.05). Blood pressure success rate was 41.3% in the control group

which was lower than that of 65.9% in the observation group (P<0.05). The CysC and β2-MG standards in the observation group were lower than those in the control group (P<0.01). After therapy

the ET-1 level in two groups declined

while the result was more obvious in the observation group (P<0.01). However

the NO in both groups went up

while the result was more obvious in the observation group (P<0.01). Conclusion: Based on the conventional Western medicine treatment

Bushen Pinggan decoction for oral and bath foot could control the blood pressure level

improve blood pressure success rate in refractory hypertension patients. Besides

it has a certain protective effect on early renal damage of hypertension. The mechanism may be related to regulating endothelial function.