Bushen Huoxue Mingmu Decoction in Treating 50 Patients with Non-propagative Daibetic Retinopathy

TAN Hui; WANG Kang

doi:10.13422/j.cnki.syfjx.2015120178

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Bushen Huoxue Mingmu Decoction in Treating 50 Patients with Non-propagative Daibetic Retinopathy

更新时间：2024-01-04

- Bushen Huoxue Mingmu Decoction in Treating 50 Patients with Non-propagative Daibetic Retinopathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 12, Pages: 178-181(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015120178
  CLC： R259;R276.7
- Published：2015
- 稿件说明：
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TAN Hui, WANG Kang. Bushen Huoxue Mingmu Decoction in Treating 50 Patients with Non-propagative Daibetic Retinopathy[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(12): 178-181.
DOI：

TAN Hui, WANG Kang. Bushen Huoxue Mingmu Decoction in Treating 50 Patients with Non-propagative Daibetic Retinopathy[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(12): 178-181. DOI： 10.13422/j.cnki.syfjx.2015120178.

摘要

目的: 探讨补肾活血明目汤治疗肝肾亏虚

络脉瘀阻证非增殖型糖尿病视网膜病变(NPDR)的临床疗效及对血管内皮细胞生长因子(VEGF)和肿瘤坏死因子-α(TNF-α)影响。方法: 将97例患者随机按数字表法分为对照组47例(91眼)和观察组50例(95眼)。对照组有效控制血糖

并给予缬沙坦胶囊

80 mg/次

1次/d;辛伐他汀片

40 mg/次

1次/d

晚上服用;阿司匹林肠溶片

100 mg/次

1次/d

羟苯磺酸钙胶囊

0.5 g/次

3次/d

口服。观察组在对照组治疗的基础上加用丹补肾活血明目汤

1剂/d。两组疗程均为12周。进行治疗前后视力和眼底检查及中医证候积分;检测治疗后甘油三酯(TG)

总胆固醇(TC)

高密度脂蛋白胆固醇(HDL-C)

低密度脂蛋白胆固醇(LDL-C)

TNF-α和VEGF水平。结果: 观察组眼底病变疗效总有效率86.3%

对照组70.3%

观察组优于对照组(P<0.05);治疗后观察组视力好于对照组(P<0.01);治疗后观察组眼底检查和中医证候评分低于对照组(P<0.01);治疗后两组TG

TC和LDL-C水平较治疗前下降(P<0.01)

治疗后观察组LDL-C水平低于对照组(P<0.01)

观察组HDL-C升高并高于对照组(P<0.01);治疗后观察组TNF-α

VEGF水平低于对照组(P<0.01)。结论: 在西医常规治疗的基础上

补肾活血明目汤能提高NPDR视力

改善症状、体征

临床疗效优于单纯西医治疗

其作用机制可能与调节脂代谢

降低TNF-α和VEGF水平有关。

Abstract

Objective: To discuss the clinical efficacy of Bushen Huoxue Mingnu decoction in treating non-propagative diabetic retinopathy (NPDR) with the deficiency of liver and kidney combined collaterals stasis resistance of tradition Chinese medical (TCM) syndrome

and to investigate its influence on vascular endothelial cell growth factor (VEGF) and tumor necrosis factor-α (TNF-α). Method: Ninety-seven patients were randomly divided into the control group (47 cases) and the observation group (50 cases) by a random number table. Patients in the control group received 80 mg valsartan capsules once daily for controlling the blood glucose

40 mg simvastatin tablets once nightly

100 mg aspirin enteric-coated tablets once daily

and 0.5 g calcium dobesilate capsules thrice daily. Based on the treatment of the control group

patients in the observation added 1 dose Bushen Huoxue Mingnu decoction. All patients in both two groups received 12 weeks of treatment. Before and after treatment

vision and fundus examination were made and scores of TCM syndrome were graded. Levels of triglyceride (TG)

total cholestero l(TC)

high density lipoprotein cholesterol (HDL-C)

and low density lipoprotein cholesterol (LDL-C)

TNF-α and VEGF were detected. Result: The total effective rate of fundus lesions in the observation group was 86.3%

which was superior to that of 70.3% in the control group (P<0.05). After therapy

vision in the observation group was better than that in the control group (P<0.01). The inspection and TCM syndrome score in the observation group were lower than those in the control group (P<0.01). Levels of TG

TC and LDL-C declined after treatment in both two groups compared before (P<0.01). The LDL-C level in the observation group was lower (P<0.01)

while the HDL-C standard was higher than those in the control group (P<0.01). After treatment

TNF-α and VEGF levels in the observation group were lower than those in the control group (P<0.01). Conclusion: Based on the conventional Western treatment

Bushen Huoxue Mingmu decoction could improve vision

signs and symptoms of NPDR patients. Its clinical curative effect is superior to using Western medicine treatment alone. The mechanism may be related to regulating lipid metabolism

reducing TNF-α and VEGF levels.

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