Objective: To discuss the clinical effect of Tiaochong Jieyu decoction in treating depression of perimenopausal

and to investigate its influence on levels of estrogen (E2)

follicle-stimulating hormone (FSH)

luteinizing hormone (LH) and 5-hydroxytryptamine (5-HT). Method: One hundred and twenty patients were randomly divided into the control group (60 cases) and the observation group (60 cases) by a random number table. All patients in both groups received 2.5 mg tibolone tablets once daily. Patients in the control group added 2 flupentixol and melitracen tablets in the morning and noon. Patients in the observation added Tiaochong Jieyu decoction. All patients in two groups received 8 weeks of treatment. Before and at the fourth and the eighth week after treatment

sores of Hamilton depression scale (HAMD)

Hamilton Anxiety Rating Scale (HAMA)

Pittsburgh sleep quality index (PSQI) and Kupperman were graded. Levels of E2

FSH

LH and 5-HT were detected

and adverse reactions were monitored. Result: The total clinical efficiency of depression in the observation group was 90%

which was 86.67% in the control group. There was no statistical significance difference between the two groups. Total clinical efficient of syndrome of perimenopausal in the observation group was 91.67%

which was superior to that of 76.67% in the control group (P<0.05). There was no statistical significance difference for HAMD scores between the two groups. HAMA scores were lower at the eighth week after treatment

sores of PSQI and Kupperman were lower at the fourth and eighth week after treatment in the observation group than those in the control group (P<0.01). Besides

the results of HAMA

PSQI and Kupperman were more obvious in the observation group (P<0.01). After treatment

levels of FSH and LH were lower (P<0.01)

and levels of E2and 5-HT were higher (P<0.01) in the observation group than those in the control group. The rate of adverse reaction was 18.3% in the control group

and there was no adverse reaction in the observation group. Conclusion: Based on the treatment of estrogen replacement therapy

the curative effect of Tiaochong Jieyu decoction was the same as flupentixol and melitracen tablets

while there was rare side effect. Moreover

there was obvious amelioration on sleep and syndrome in menopause

its mechanism of action may be related to regulating levels of neuroendocrine hormone.