Objective: To optimize extraction process of Bushen Quyu granules. Method: UV was adopted to determine contents of total polysaccharides and total flavonoids with detection wavelength at 489 nm and 510 nm.HPLC was used to determine the content of stilbene glycoside with mobile phase of acetonitrile-water(22: 78) and detection wavelength at 320 nm.Taking total polysaccharides yield as index

orthogonal test was adopted to investigate effects of solid-liquid ratio

extraction time and times

alcohol precipitation concentration on water extraction process;taking comprehensive score of yields of total flavonoids

stilbene glycoside and extract as index

effects of ethanol concentration

ethanol amount

extraction time and times on alcohol extraction process were optimized by orthogonal test. Result: Optimum water extraction process was as follows:soaked 1 h and refluxing extracted thrice with 12 times the amount of water for 1.5 h each time

alcohol precipitation concentration of 80%;yield of total polysaccharides reached 8.682%.Optimum ethanol extraction process was:refluxing extracted thrice with 10 times the amount of 80% ethanol for 1.5 h each time;yields of total flavonoids

stilbene glycoside and extract reached 660.19 mg·g-1

145.91 μg·g-1

11.81%

respectively. Conclusion: These optimized extraction processes are repeatable and feasible to provide basis for industry production of Bushen Quyu granules.